ID   YES-2
AC   CVCL_E322
SY   YES 2; YES2
DR   cancercelllines; CVCL_E322
DR   Cosmic; 2395009
DR   GEO; GSM301575
DR   Progenetix; CVCL_E322
DR   Wikidata; Q54995400
RX   CelloPub=CLPUB00005;
RX   DOI=10.5833/jjgs.27.1885;
RX   PubMed=1770930;
RX   PubMed=8590302;
RX   PubMed=8974001;
RX   PubMed=11115554;
RX   PubMed=18575732;
RX   PubMed=18973137;
RX   PubMed=20515944;
RX   PubMed=21191746;
CC   Population: Japanese.
CC   Doubling time: 22.9 hours (PubMed=1770930); 67.2 hours (DOI=10.5833/jjgs.27.1885); 23.7 hours (Note=At 102th passage) (CelloPub=CLPUB00005).
CC   HLA typing: A*24; B*01,40; C*03,07 (PubMed=18575732).
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Variations; Array-based CGH.
CC   Derived from site: In situ; Esophagus; UBERON=UBERON_0001043.
DI   NCIt; C4024; Esophageal squamous cell carcinoma
DI   ORDO; Orphanet_99977; Squamous cell carcinoma of the esophagus
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   81Y
CA   Cancer cell line
DT   Created: 22-10-12; Last updated: 10-04-25; Version: 17
CH   CVCL_S526 ! YES-2CSC
//
RX   PubMed=8974001; DOI=10.1089/jir.1996.16.1001;
RA   Oka, Masaaki
RA   Iizuka, Norio
RA   Yamamoto, Kohtaro
RA   Gondo, Toshikazu
RA   Abe, Toshihiro
RA   Hazama, Shoichi
RA   Akitomi, Yumiko
RA   Koishihara, Yoshio
RA   Ohsugi, Yoshiyuki
RA   Ooba, Yuzou
RA   Ishihara, Tokuhiro
RA   Suzuki, Takashi
RT   "The influence of interleukin-6 on the growth of human esophageal
RT   cancer cell lines.";
RL   J. Interferon Cytokine Res. 16:1001-1006(1996).
//
RX   PubMed=11115554; DOI=10.3892/ijo.18.1.157;
RA   Fujii, Teruhiko
RA   Kato, Seiya
RA   Yamana, Hideaki
RA   Tanaka, Yuichi
RA   Fujita, Hiromasa
RA   Shirouzu, Kazuo
RA   Morimatsu, Minoru
RT   "Expression of G1 cell cycle markers and the effect of
RT   adenovirus-mediated overexpression of p21Waf-1 in squamous cell
RT   carcinoma of the esophagus.";
RL   Int. J. Oncol. 18:157-163(2001).
//
RX   PubMed=21191746; DOI=10.1007/s11684-010-0260-x;
RA   Ji, Jun-Fang
RA   Wu, Kun
RA   Wu, Min
RA   Zhan, Qi-Min
RT   "p53 functional activation is independent of its genotype in five
RT   esophageal squamous cell carcinoma cell lines.";
RL   Front. Med. China 4:412-418(2010).
//
RX   PubMed=20515944; DOI=10.1158/1535-7163.MCT-09-0918; PMCID=PMC2884061;
RA   Seki, Naoko
RA   Toh, Uhi
RA   Sayers, Thomas J.
RA   Fujii, Teruhiko
RA   Miyagi, Motoshi
RA   Akagi, Yoshito
RA   Kusukawa, Jingo
RA   Kage, Masayoshi
RA   Shirouzu, Kazuo
RA   Yamana, Hideaki
RT   "Bortezomib sensitizes human esophageal squamous cell carcinoma cells
RT   to TRAIL-mediated apoptosis via activation of both extrinsic and
RT   intrinsic apoptosis pathways.";
RL   Mol. Cancer Ther. 9:1842-1851(2010).
//
RX   PubMed=8590302; DOI=10.1089/jir.1995.15.1005;
RA   Oka, Masaaki
RA   Hirose, Kunitaka
RA   Iizuka, Norio
RA   Aoyagi, Keiko
RA   Yamamoto, Kohtaro
RA   Abe, Toshihiro
RA   Hazama, Shoichi
RA   Suzuki, Takashi
RT   "Cytokine mRNA expression patterns in human esophageal cancer cell
RT   lines.";
RL   J. Interferon Cytokine Res. 15:1005-1009(1995).
//
RX   CelloPub=CLPUB00005;
RA   Nakamura, Masayuki
RA   Murakami, Takuo
RA   Sakata, Koichiro
RA   Kusanagi, Hiroshi
RA   Saeki, Toshihiro
RA   Uchisako, Hiroyuki
RA   Hayashi, Hiroto
RA   Tangoku, Akira
RA   Suzuki, Takashi
RT   "Establishment and characterization of a new human esophageal cancer
RT   cell line (YES-2).";
RL   Bull. Yamaguchi Med. Sch. 41:149-153(1994).
//
RX   DOI=10.5833/jjgs.27.1885;
RA   Kusanagi, Hiroshi
RT   "Effect of epidermal growth factor (EGF) on human esophageal cancer
RT   cell lines in a protein-free medium and the expression of EGF
RT   receptors on the cells.";
RL   Nihon Shokaki Geka Gakkai Zasshi 27:1885-1891(1994).
//
RX   PubMed=18575732; DOI=10.3892/or.20.1.155;
RA   Kawaoka, Toru
RA   Oka, Masaaki
RA   Takashima, Motonari
RA   Ueno, Tomio
RA   Yamamoto, Koutaro
RA   Yahara, Noboru
RA   Yoshino, Shigefumi
RA   Hazama, Shoichi
RT   "Adoptive immunotherapy for pancreatic cancer: cytotoxic T lymphocytes
RT   stimulated by the MUC1-expressing human pancreatic cancer cell line
RT   YPK-1.";
RL   Oncol. Rep. 20:155-163(2008).
//
RX   PubMed=18973137; DOI=10.1002/gcc.20626;
RA   Sugimoto, Takashi
RA   Seki, Naohiko
RA   Shimizu, Satoya
RA   Kikkawa, Naoko
RA   Tsukada, Jun
RA   Shimada, Hideaki
RA   Sasaki, Keita
RA   Hanazawa, Toyoyuki
RA   Okamoto, Yoshitaka
RA   Hata, Akira
RT   "The galanin signaling cascade is a candidate pathway regulating
RT   oncogenesis in human squamous cell carcinoma.";
RL   Genes Chromosomes Cancer 48:132-142(2009).
//
RX   PubMed=1770930;
RA   Murakami, Takuo
RA   Nakamura, Masayuki
RA   Kusanagi, Hiroshi
RA   Suzuki, Takashi
RT   "Establishment and characterization of human esophageal carcinoma cell
RT   lines -- especially the role of the serum-free culture.";
RL   Nihon Geka Gakkai Zasshi 92:1563-1570(1991).
//