• Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg249Ser (c.747G>T); ClinVar=VCV000012352; Zygosity=Unspecified (PubMed=10958934).
  

PubMed=10958934; DOI=10.1016/S0165-4608(99)00247-2
Pang E., Wong N., Lai P.B.-S., To K.-F., Lau J.W.-Y., Johnson P.J.
A comprehensive karyotypic analysis on a newly developed hepatocellular carcinoma cell line, HKCI-1, by spectral karyotyping and comparative genomic hybridization.
Cancer Genet. Cytogenet. 121:9-16(2000)

PubMed=11793441; DOI=10.1002/gcc.1220
Pang E., Wong N., Lai P.B.-S., To K.-F., Lau J.W.-Y., Johnson P.J.
Consistent chromosome 10 rearrangements in four newly established human hepatocellular carcinoma cell lines.
Genes Chromosomes Cancer 33:150-159(2002)

PubMed=15645427; DOI=10.1002/ijc.20684
Chan K.Y.-Y., Wong N., Lai P.B.-S., Squire J.A., Macgregor P.F., Beheshti B., Albert M., To K.-F., Johnson P.J.
Transcriptional profiling on chromosome 19p indicated frequent downregulation of ACP5 expression in hepatocellular carcinoma.
Int. J. Cancer 114:902-908(2005)

PubMed=15709204; DOI=10.1158/1078-0432.1319.11.3
Wong N., Chan K.Y.-Y., Macgregor P.F., Lai P.B.-S., Squire J.A., Beheshti B., Albert M., Leung T.W.-T.
Transcriptional profiling identifies gene expression changes associated with IFN-alpha tolerance in hepatitis C-related hepatocellular carcinoma cells.
Clin. Cancer Res. 11:1319-1326(2005)

PubMed=19003983; DOI=10.1002/ijc.23968
Wong N., Yeo W., Wong W.-L., Wong N.L.-Y., Chan K.Y.-Y., Mo F.K.-F., Koh J., Chan S.L., Chan A.T.-C., Lai P.B.-S., Ching A.K.-K., Tong J.H.-M., Ng H.-K., Johnson P.J., To K.-F.
TOP2A overexpression in hepatocellular carcinoma correlates with early age onset, shorter patients survival and chemoresistance.
Int. J. Cancer 124:644-652(2009)

PubMed=24582836; DOI=10.1016/j.ccr.2014.01.030
Lau C.-C., Sun T.-T., Ching A.K.-K., He M., Li J.-W., Wong A.M., Co N.N., Chan A.W.-H., Li P.-S., Lung R.W.-M., Tong J.H.-M., Lai P.B.-S., Chan H.L.-Y., To K.-F., Chan T.-F., Wong N.
Viral-human chimeric transcript predisposes risk to liver cancer development and progression.
Cancer Cell 25:335-349(2014)