ID   BxPC-3 SMAD3 KO
AC   CVCL_E2X6
SY   S3-KO BxPC-3
RX   PubMed=36207615;
CC   Population: Caucasian.
CC   Knockout cell: Method=CRISPR/Cas9; HGNC; 6769; SMAD3.
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Gene deletion; HGNC; 6770; SMAD4; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Val487_Pro492delinsAla (c.1460_1474delGTGTAGGTGCTGTCA); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; None_reported; -; Zygosity=- (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Tyr220Cys (c.659A>G); ClinVar=VCV000127819; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Pancreas; UBERON=UBERON_0001264.
DI   NCIt; C9120; Pancreatic ductal adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0186 ! BxPC-3
SX   Female
AG   61Y
CA   Cancer cell line
DT   Created: 10-09-24; Last updated: 10-09-24; Version: 1
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RX   PubMed=36207615; DOI=10.1038/s42003-022-03994-6; PMCID=PMC9546935;
RA   Bertrand-Chapel A., Caligaris C., Fenouil T., Savary C., Aires S.,
RA   Martel S., Huchede P., Chassot C., Chauvet V., Cardot-Ruffino V.,
RA   Morel A.-P., Subtil F., Mohkam K., Mabrut J.-Y., Tonon L., Viari A.,
RA   Cassier P., Hervieu V., Castets M., Mauviel A., Sentis S., Bartholin L.;
RT   "SMAD2/3 mediate oncogenic effects of TGF-beta in the absence of
RT   SMAD4.";
RL   Commun. Biol. 5:1068.1-1068.13(2022).
//