| Cell line name |
BxPC-3 SMAD2/SMAD3 DKO |
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| Synonyms |
S2/3-KO BxPC-3 |
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| Accession |
CVCL_E2X5 |
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| Resource Identification Initiative |
To cite this cell line use: BxPC-3 SMAD2/SMAD3 DKO (RRID:CVCL_E2X5) |
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| Comments |
Population: Caucasian.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:6768; SMAD2.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:6769; SMAD3.
Derived from site: In situ; Pancreas; UBERON=UBERON_0001264. |
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| Sequence variations |
- Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
- Gene deletion; HGNC; HGNC:6770; SMAD4; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val487_Pro492delinsAla (c.1460_1474delGTGTAGGTGCTGTCA); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6407; KRAS; None_reported; -; Zygosity=- (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr220Cys (c.659A>G); ClinVar=VCV000127819; Zygosity=Homozygous (from parent cell line).
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| Disease |
Pancreatic ductal adenocarcinoma (NCIt: C9120) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0186 (BxPC-3) |
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| Sex of cell |
Female |
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| Age at sampling |
61Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=36207615; DOI=10.1038/s42003-022-03994-6; PMCID=PMC9546935
Bertrand-Chapel A., Caligaris C., Fenouil T., Savary C., Aires S., Martel S., Huchede P., Chassot C., Chauvet V., Cardot-Ruffino V., Morel A.-P., Subtil F., Mohkam K., Mabrut J.-Y., Tonon L., Viari A., Cassier P., Hervieu V., Castets M., Mauviel A., Sentis S., Bartholin L.
SMAD2/3 mediate oncogenic effects of TGF-beta in the absence of SMAD4.
Commun. Biol. 5:1068.1-1068.13(2022) |
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| Entry history |
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| Entry creation | 10-Sep-2024 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 2 |
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