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Cellosaurus BxPC-3 SMAD2/SMAD3 DKO (CVCL_E2X5)

[Text version]
Cell line name BxPC-3 SMAD2/SMAD3 DKO
Synonyms S2/3-KO BxPC-3
Accession CVCL_E2X5
Resource Identification Initiative To cite this cell line use: BxPC-3 SMAD2/SMAD3 DKO (RRID:CVCL_E2X5)
Comments Population: Caucasian.
Knockout cell: Method=CRISPR/Cas9; HGNC; 6768; SMAD2.
Knockout cell: Method=CRISPR/Cas9; HGNC; 6769; SMAD3.
Derived from site: In situ; Pancreas; UBERON=UBERON_0001264.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; 6770; SMAD4; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val487_Pro492delinsAla (c.1460_1474delGTGTAGGTGCTGTCA); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; None_reported; -; Zygosity=- (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Tyr220Cys (c.659A>G); ClinVar=VCV000127819; Zygosity=Homozygous (from parent cell line).
Disease Pancreatic ductal adenocarcinoma (NCIt: C9120)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0186 (BxPC-3)
Sex of cell Female
Age at sampling 61Y
Category Cancer cell line
Publications

PubMed=36207615; DOI=10.1038/s42003-022-03994-6; PMCID=PMC9546935
Bertrand-Chapel A., Caligaris C., Fenouil T., Savary C., Aires S., Martel S., Huchede P., Chassot C., Chauvet V., Cardot-Ruffino V., Morel A.-P., Subtil F., Mohkam K., Mabrut J.-Y., Tonon L., Viari A., Cassier P., Hervieu V., Castets M., Mauviel A., Sentis S., Bartholin L.
SMAD2/3 mediate oncogenic effects of TGF-beta in the absence of SMAD4.
Commun. Biol. 5:1068.1-1068.13(2022)

Entry history
Entry creation10-Sep-2024
Last entry update10-Sep-2024
Version number1