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Cellosaurus HP-alphaIIbbeta3 (CVCL_E2T9)

[Text version]
Cell line name HP-alphaIIbbeta3
Accession CVCL_E2T9
Resource Identification Initiative To cite this cell line use: HP-alphaIIbbeta3 (RRID:CVCL_E2T9)
Comments Population: Caucasian.
Biotechnology: Used in assay systems for the detection of HPA-1a, HPA-3a, HPA-6a and HPA-7a antibodies (PubMed=21208305).
Genetic integration: Method=Transfection/transduction; Gene=HGNC; 6138; ITGA2B.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; 6156; ITGB3.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; 76; ABL1 + HGNC; 1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
Disease Blast phase chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C9110)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0004 (K-562)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
Publications

PubMed=21208305; DOI=10.1111/j.1365-3148.2010.01064.x
Hayashi T., Amakishi E., Matsuyama N., Yasui K., Furuta R.A., Hori Y., Tanaka S., Fukumori Y., Hirayama F., Inoue M.
Establishment of a cell line panel as an alternative source of platelet antigens for a screening assay of anti-human platelet antibodies.
Transfus. Med. 21:199-204(2011)

Entry history
Entry creation10-Sep-2024
Last entry update10-Sep-2024
Version number1