Cellosaurus cell line OvBRCA2 (CVCL

Cellosaurus OvBRCA2 (CVCL_E2T1)

Entry history
Cell line name	OvBRCA2
Accession	CVCL_E2T1
Resource Identification Initiative	To cite this cell line use: OvBRCA2 (RRID:CVCL_E2T1)
Comments	Genetic integration: Method=Transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP). Genetic integration: Method=Transduction; Gene=FPbase; KETFB; OFP (Note=Orange fluorescent protein from Cerianthus sp.). Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT. Genetic integration: Method=Transduction; Gene=MGI; MGI:88174; Bmi1. Genetic integration: Method=Transduction; Gene=UniProtKB; P03070; SV40 large T antigen. Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40). Omics: Transcriptomics; RNAseq. Derived from site: In situ; Ovary; UBERON=UBERON_0000992. Cell type: Epithelial cell of ovary; CL=CL_2000064.
Sequence variations	Mutation; HGNC; HGNC:1101; BRCA2; Simple; p.Ile605Thrfs*9 (c.1813delA); ClinVar=VCV000037763; Zygosity=Unspecified (PubMed=38615309).
Disease	BRCA2 syndrome (NCIt: C36101) Hereditary breast and ovarian cancer syndrome (ORDO: Orphanet_145)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Female
Age at sampling	53Y
Category	Transformed cell line
Publications	PubMed=38615309; DOI=10.1007/s13577-024-01064-z Komatsu H., Okawa M., Kazuki Y., Kazuki K., Hichiwa G., Shimoya K., Sato S., Taniguchi F., Oshimura M., Harada T. Characterization of immortalized ovarian epithelial cells with BRCA1/2 mutation. Hum. Cell 37:986-996(2024)
Entry creation	10-Sep-2024
Last entry update	10-Apr-2025
Version number	3