ID   HAP1 EIF2AK1 (-) EIF2AK4 (-) 1
AC   CVCL_E1NS
SY   HZGHC008247c001; Double knockout cell line EIF2AK1 1bp deletion in exon 2 and EIFA2K4 11bp deletion in exon 4
DR   Horizon_Discovery; HZGHC008247c001
CC   Group: Haploid karyotype cell line.
CC   Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:24921; EIF2AK1.
CC   Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:19687; EIF2AK4.
CC   Sequence variation: Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 13 fused to ABL1 exon 2 (b2a2 transcript) (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ser215Gly (c.643A>G); ClinVar=VCV000265337; Zygosity=Hemizygous (from parent cell line).
CC   Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
DI   NCIt; C3174; Chronic myelogenous leukemia, BCR-ABL1 positive
DI   ORDO; Orphanet_521; Chronic myeloid leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_SL63 ! HAP1 EIF2AK1 (-)
SX   Male
AG   40Y
CA   Cancer cell line
DT   Created: 10-09-24; Last updated: 19-12-24; Version: 2
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