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Cellosaurus HyCyte U-937 KO-hPTPRA (CVCL_E1N8)

[Text version]
Cell line name HyCyte U-937 KO-hPTPRA
Synonyms hPTPRA knockout U-937
Accession CVCL_E1N8
Resource Identification Initiative To cite this cell line use: HyCyte U-937 KO-hPTPRA (RRID:CVCL_E1N8)
Comments Population: Caucasian.
Doubling time: 48-72 hours (Hysigen=CGKO-M2708).
Knockout cell: Method=CRISPR/Cas9; HGNC; 9664; PTPRA.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; 16063; MLLT10 + HGNC; 15514; PICALM; Name(s)=PICALM-MLLT10, CALM-AF10 (from parent cell line).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Gly129fs*51 (c.387_388insCGCC); Zygosity=Hemizygous (from parent cell line).
  • Mutation; HGNC; 9644; PTPN11; Simple; p.Gly60Arg (c.178G>C); ClinVar=VCV000372590; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; c.559+1G>A (p.Val173Trpfs*59); ClinVar=VCV000428908; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
  • Mutation; HGNC; 12796; WT1; Simple; p.Arg301Ter (c.901C>T) (p.Arg352Ter, c.1054C>T) (p.Arg374Ter, c.1120C>T); ClinVar=VCV000449416; Zygosity=Heterozygous (from parent cell line).
Disease Adult acute monocytic leukemia (NCIt: C8263)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0007 (U-937)
Sex of cell Male
Age at sampling 37Y
Category Cancer cell line
Cross-references
Cell line collections (Providers) Hysigen; CGKO-M2708
Entry history
Entry creation10-Sep-2024
Last entry update10-Sep-2024
Version number1