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Cellosaurus HyCyte HL-60 KO-hIRAK4 (CVCL_E1LB)

[Text version]
Cell line name HyCyte HL-60 KO-hIRAK4
Synonyms hIRAK4 knockout HL-60
Accession CVCL_E1LB
Resource Identification Initiative To cite this cell line use: HyCyte HL-60 KO-hIRAK4 (RRID:CVCL_E1LB)
Comments Population: Caucasian.
Doubling time: 48-72 hours (Hysigen=CGKO-M2295).
Knockout cell: Method=CRISPR/Cas9; HGNC; 17967; IRAK4.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene deletion; HGNC; 11998; TP53; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
Disease Adult acute myeloid leukemia (NCIt: C9154)
Acute myeloid leukemia (ORDO: Orphanet_519)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0002 (HL-60)
Sex of cell Female
Age at sampling 36Y
Category Cancer cell line
Cross-references
Cell line collections (Providers) Hysigen; CGKO-M2295
Entry history
Entry creation10-Sep-2024
Last entry update10-Sep-2024
Version number1