ID   IMA-KO-1-IDH1
AC   CVCL_E1HZ
RX   PubMed=23204232;
CC   Knockout cell: Method=Homologous recombination; HGNC; HGNC:5382; IDH1 (Note=1 of 2 alleles).
CC   Sequence variation: Mutation; HGNC; HGNC:886; ATRX; Simple; p.Arg781Ter (c.2341C>T); Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:5382; IDH1; Simple; p.Arg132His (c.395G>A); ClinVar=VCV000156444; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly245Val (c.734G>T); ClinVar=VCV000376603; Zygosity=Unspecified (from parent cell line).
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:5382; IDH1.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P33967; B.cereus Bsr.
CC   Derived from site: In situ; Brain; UBERON=UBERON_0000955.
DI   NCIt; C9477; Anaplastic astrocytoma
DI   ORDO; Orphanet_251589; Anaplastic astrocytoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_E1HW ! IMA-KO-1
SX   Male
AG   26Y
CA   Cancer cell line
DT   Created: 10-09-24; Last updated: 19-12-24; Version: 2
//
RX   PubMed=23204232; DOI=10.1158/0008-5472.CAN-12-2852; PMCID=PMC3548957;
RA   Jin G.-L., Reitman Z.J., Duncan C.G., Spasojevic I., Gooden D.M.,
RA   Rasheed B.K.A., Yang R., Lopez G.Y., He Y.-P., McLendon R.E.,
RA   Bigner D.D., Yan H.;
RT   "Disruption of wild-type IDH1 suppresses D-2-hydroxyglutarate
RT   production in IDH1-mutated gliomas.";
RL   Cancer Res. 73:496-501(2013).
//