ID   WTC11 AAVS1-NEUROG2 SYNJ1-KO
AC   CVCL_E1HU
SY   SYNJ1 KO WTC11; SJ1 KO iPSC
RX   PubMed=38635628;
CC   Population: Japanese.
CC   Characteristics: Using TALEN a PuroR-CAG-rtTA3G-NEUROG2 construct was introduced in both alleles of the AAVS1 safe harbor locus thus providing doxycycline-inducible expression of NEUROG2/NGN2 (from parent cell line).
CC   Knockout cell: Method=CRISPR/Cas9; HGNC; 11503; SYNJ1.
CC   Genetic integration: Method=TALEN; Gene=HGNC; 13805; NEUROG2.
CC   Genetic integration: Method=TALEN; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
CC   Derived from site: In situ; Leg, skin; UBERON=UBERON_0001511.
CC   Cell type: Fibroblast of skin; CL=CL_0002620.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_C7XJ ! Pre-i3Neuron NGN2 iPSC clone 1
SX   Male
AG   30Y
CA   Induced pluripotent stem cell
DT   Created: 10-09-24; Last updated: 10-09-24; Version: 1
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RX   PubMed=38635628; DOI=10.1073/pnas.2318943121; PMCID=PMC11047088;
RA   Mohd Rafiq N.B., Fujise K., Rosenfeld M.S., Xu P., De Camilli P.;
RT   "Parkinsonism Sac domain mutation in synaptojanin-1 affects ciliary
RT   properties in iPSC-derived dopaminergic neurons.";
RL   Proc. Natl. Acad. Sci. U.S.A. 121:e2318943121.1-e2318943121.12(2024).
//