ID   N2a[TRb1]-274B Clone A1
AC   CVCL_E1GV
DR   Kerafast; EMU059
RX   PubMed=27387481;
CC   Characteristics: Using CRISPR/Cas9 mutations were introduced in the thyroid hormone response element (TRE) of the Dnmt3a gene (PubMed=27387481).
CC   Genetic integration: Method=Transfection; Gene=HGNC; 11799; THRB.
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
CC   Derived from site: In situ; Peripheral nervous system; UBERON=UBERON_0000010.
CC   Cell type: Neural crest derived neuroblast; CL=CL_0002676.
CC   Breed/subspecies: A/J.
DI   NCIt; C21993; Mouse neuroblastoma
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
HI   CVCL_E1GT ! Neuro2A[TRb1]
SX   Male
CA   Cancer cell line
DT   Created: 10-09-24; Last updated: 10-09-24; Version: 1
//
RX   PubMed=27387481; DOI=10.1210/en.2015-1529; PMCID=PMC5007891;
RA   Kyono Y., Subramani A., Ramadoss P., Hollenberg A.N., Bonett R.M.,
RA   Denver R.J.;
RT   "Liganded thyroid hormone receptors transactivate the DNA
RT   methyltransferase 3a gene in mouse neuronal cells.";
RL   Endocrinology 157:3647-3657(2016).
//