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Cellosaurus Ubigene U-87 MG SIRT3 KO (CVCL_E1EP)

[Text version]
Cell line name Ubigene U-87 MG SIRT3 KO
Synonyms SIRT3 Knockout cell line (U-87 MG)
Accession CVCL_E1EP
Resource Identification Initiative To cite this cell line use: Ubigene U-87 MG SIRT3 KO (RRID:CVCL_E1EP)
Comments Problematic cell line: Misidentified. Parent cell line (U-87MG ATCC) is not the original glioblastoma cell line established in 1968 at the University of Uppsala.
Population: Caucasian.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:14931; SIRT3.
Sequence variations
  • Mutation; HGNC; HGNC:7765; NF1; Simple; p.Phe1247Ilefs*18 (c.3739_3742delTTTG) (3737_3740delTGTT); ClinVar=VCV000420078; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; c.209+1G>T; ClinVar=VCV000229705; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Glioblastoma (NCIt: C3058)
Glioblastoma (ORDO: Orphanet_360)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0022 (U-87MG ATCC)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
Cross-references
Cell line collections (Providers) Ubigene; YKO-H252
Entry history
Entry creation10-Sep-2024
Last entry update19-Dec-2024
Version number2