Cellosaurus cell line Ubigene U-87 MG SIRT3 KO (CVCL

Cross-references
Cell line name	Ubigene U-87 MG SIRT3 KO
Synonyms	SIRT3 Knockout cell line (U-87 MG)
Accession	CVCL_E1EP
Resource Identification Initiative	To cite this cell line use: Ubigene U-87 MG SIRT3 KO (RRID:CVCL_E1EP)
Comments	Problematic cell line: Misidentified. Parent cell line (U-87MG ATCC) is not the original glioblastoma cell line established in 1968 at the University of Uppsala. Population: Caucasian. Knockout cell: Method=CRISPR/Cas9; HGNC; 14931; SIRT3.
Sequence variations	Mutation; HGNC; 7765; NF1; Simple; p.Phe1247Ilefs*18 (c.3739_3742delTTTG) (3737_3740delTGTT); ClinVar=VCV000420078; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; 9588; PTEN; Simple; c.209+1G>T; ClinVar=VCV000229705; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line). Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease	Glioblastoma (NCIt: C3058) Glioblastoma (ORDO: Orphanet_360)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0022 (U-87MG ATCC)
Sex of cell	Male
Age at sampling	Age unspecified
Category	Cancer cell line
Cell line collections (Providers)	Ubigene; YKO-H252
Entry history
Entry creation	10-Sep-2024
Last entry update	10-Sep-2024
Version number	1