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Cellosaurus SK-MEL-321B (CVCL_E089)

[Text version]
Cell line name SK-MEL-321B
Synonyms SK-Mel-321B; SKMEL-321B
Accession CVCL_E089
Resource Identification Initiative To cite this cell line use: SK-MEL-321B (RRID:CVCL_E089)
Comments From: Memorial Sloan Kettering Cancer Center; New York; USA.
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_D771 ! SK-MEL-321A
Category Cancer cell line
Publications

PubMed=21725359; DOI=10.1038/onc.2011.250; PMCID=PMC3267014
Xing F., Persaud Y., Pratilas C.A., Taylor B.S., Janakiraman M., She Q.-B., Gallardo H.F., Liu C., Merghoub T., Hefter B.E., Dolgalev I., Viale A.J., Heguy A., de Stanchina E., Cobrinik D., Bollag G., Wolchok J.D., Houghton A.N., Solit D.B.
Concurrent loss of the PTEN and RB1 tumor suppressors attenuates RAF dependence in melanomas harboring (V600E)BRAF.
Oncogene 31:446-457(2012)

PubMed=24576830; DOI=10.1158/0008-5472.CAN-13-2625; PMCID=PMC4005042
Nissan M.H., Pratilas C.A., Jones A.M., Ramirez R., Won H., Liu C.-L., Tiwari S., Kong L., Hanrahan A.J., Yao Z., Merghoub T., Ribas A., Chapman P.B., Yaeger R.D., Taylor B.S., Schultz N., Berger M.F., Rosen N., Solit D.B.
Loss of NF1 in cutaneous melanoma is associated with RAS activation and MEK dependence.
Cancer Res. 74:2340-2350(2014)

Cross-references
Encyclopedic resources Wikidata; Q54954079
Polymorphism and mutation databases Cosmic; 1669245
Entry history
Entry creation22-Oct-2012
Last entry update21-Mar-2023
Version number10