Cellosaurus K-562 dCas9-VPR (CVCL_DX78)
| Cell line name | K-562 dCas9-VPR |
|---|---|
| Accession | CVCL_DX78 |
| Resource Identification Initiative | To cite this cell line use: K-562 dCas9-VPR (RRID:CVCL_DX78) |
| Comments | Population: Caucasian. Characteristics: Transduced with a lentiviral vector EF1a-Bsd-T2A-dCas9-VPR-WPRE, where VPR is a tripartite activation system made of a fusion of VP64, p65(relA), and RTA (Horizon_Discovery=HD+dCas9-VPR-005). Genetic integration: Method=Transduction; Gene=UniProtKB; Q99ZW2; Streptomyces pyogenes Cas9 (Note=With p.Asp10Ala and p.His840Ala = dCas9). Genetic integration: Method=Transduction; Gene=UniProtKB; P0C2P0; Aspergillus terreus blasticidin-S deaminase (Bsd). Genetic integration: Method=Transduction; Gene=MGI; MGI:103290; Rela (Note=With p.Met1_Leu368 del). Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175. |
| Sequence variations | |
| Disease | Blast phase chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C9110) Chronic myeloid leukemia (ORDO: Orphanet_521) |
| Species of origin | Homo sapiens (Human) (NCBI Taxonomy: 9606) |
| Hierarchy | Parent: CVCL_0004 (K-562) |
| Sex of cell | Female |
| Age at sampling | 53Y |
| Category | Cancer cell line |
| Cross-references | |
| Cell line collections (Providers) | Horizon_Discovery; HD+dCas9-VPR-005 |
| Encyclopedic resources | Wikidata; Q127382405 |
| Entry history | |
| Entry creation | 30-Jan-2024 |
| Last entry update | 10-Sep-2024 |
| Version number | 3 |