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Cellosaurus K-562 Cas9 (CVCL_DX77)

[Text version]
Cell line name K-562 Cas9
Accession CVCL_DX77
Resource Identification Initiative To cite this cell line use: K-562 Cas9 (RRID:CVCL_DX77)
Comments Population: Caucasian.
Characteristics: Transduced with a lentiviral vector EF1a-Bsd-T2A-Cas9-WPRE (Horizon_Discovery=HD+Cas9-005).
Genetic integration: Method=Transduction; Gene=UniProtKB; Q99ZW2; Streptomyces pyogenes Cas9.
Genetic integration: Method=Transduction; Gene=UniProtKB; P0C2P0; Aspergillus terreus blasticidin-S deaminase (Bsd).
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; 76; ABL1 + HGNC; 1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
Disease Blast phase chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C9110)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0004 (K-562)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
Cross-references
Cell line collections (Providers) Horizon_Discovery; HD+Cas9-005
Encyclopedic resources Wikidata; Q127382404
Entry history
Entry creation30-Jan-2024
Last entry update10-Sep-2024
Version number3