Cellosaurus cell line HAP1 ACSL3 (-) ACSL4 (-) (CVCL

Cross-references
Cell line name	HAP1 ACSL3 (-) ACSL4 (-)
Synonyms	HZGHC007235c010; Double knockout cell line ACSL3 2bp insertion in exon 4 and ACSL4 11bp deletion in exon 3
Accession	CVCL_DX21
Resource Identification Initiative	To cite this cell line use: HAP1 ACSL3 (-) ACSL4 (-) (RRID:CVCL_DX21)
Comments	Group: Haploid karyotype cell line. Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:3570; ACSL3. Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:3571; ACSL4. Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations	Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 13 fused to ABL1 exon 2 (b2a2 transcript) (from parent cell line). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ser215Gly (c.643A>G); ClinVar=VCV000265337; Zygosity=Hemizygous (from parent cell line).
Disease	Chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C3174) Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_XK98 (HAP1 ACSL3 (-))
Sex of cell	Male
Age at sampling	40Y
Category	Cancer cell line
Cell line collections (Providers)	Horizon_Discovery; HZGHC007235c010
Encyclopedic resources	Wikidata; Q127381020
Entry history
Entry creation	30-Jan-2024
Last entry update	19-Dec-2024
Version number	4