Cellosaurus cell line DL-221 (CVCL

Cellosaurus DL-221 (CVCL_DQ91)

Cross-references
Cell line name	DL-221
Accession	CVCL_DQ91
Resource Identification Initiative	To cite this cell line use: DL-221 (RRID:CVCL_DQ91)
Comments	Doubling time: 30 hours (PubMed=27270875). Karyotypic information: Has lost chromosome Y. Omics: Deep exome analysis. Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations	Gene fusion; HGNC; HGNC:2726; DDIT3 + HGNC; HGNC:4010; FUS; Name(s)=FUS-DDIT3, TLS-CHOP (PubMed=27270875). Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (PubMed=27270875). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Thr125Arg (c.374C>G); ClinVar=VCV000376667; Zygosity=Heterozygous (PubMed=27270875). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Asn239Asp (c.715A>G); ClinVar=VCV000234036; Zygosity=Heterozygous (PubMed=27270875).
Disease	Myxoid liposarcoma (NCIt: C27781) Myxoid/round cell liposarcoma (ORDO: Orphanet_99967)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Male
Age at sampling	42Y
Category	Cancer cell line
Publications	PubMed=27270875; DOI=10.1038/labinvest.2016.64; PMCID=PMC4965313 de Graaff M.A., Yu J.S.E., Beird H.C., Ingram D.R., Nguyen T., Liu J.J.-H., Bolshakov S.V., Szuhai K., Aman P., Torres K.E., Lev D.C., Nielsen T.O., Bovee J.V.M.G., Lazar A.J.F., Somaiah N. Establishment and characterization of a new human myxoid liposarcoma cell line (DL-221) with the FUS-DDIT3 translocation. Lab. Invest. 96:885-894(2016)
Cell line databases/resources	cancercelllines; CVCL_DQ91
Encyclopedic resources	Wikidata; Q54831134
Entry history
Entry creation	13-Jul-2016
Last entry update	19-Dec-2024
Version number	13