ID   MCF7/LCC2
AC   CVCL_DP51
SY   MCF-7/LCC-2; MCF-7/LCC2; MCF-7-LCC2; LCC2
DR   cancercelllines; CVCL_DP51
DR   PRIDE; PXD000281
DR   Wikidata; Q54904469
RX   PubMed=8324732;
RX   PubMed=11078910;
RX   PubMed=23868472;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI:44616; Afimoxifene (4-hydroxytamoxifen; 4-OH TAM).
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
CC   Omics: Proteome analysis.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C4194; Invasive breast carcinoma of no special type
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_DP50 ! MCF7/LCC1
SX   Female
AG   69Y
CA   Cancer cell line
DT   Created: 13-07-16; Last updated: 05-10-23; Version: 12
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RX   PubMed=8324732;
RA   Brunner N., Frandsen T.L., Holst-Hansen C., Bei M., Thompson E.W.,
RA   Wakeling A.E., Lippman M.E., Clarke R.;
RT   "MCF7/LCC2: a 4-hydroxytamoxifen resistant human breast cancer variant
RT   that retains sensitivity to the steroidal antiestrogen ICI 182,780.";
RL   Cancer Res. 53:3229-3232(1993).
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RX   PubMed=11078910; DOI=10.1016/S0304-3835(00)00579-6;
RA   Lilling G., Hacohen H., Nordenberg J., Livnat T., Rotter V., Sidi Y.;
RT   "Differential sensitivity of MCF-7 and LCC2 cells, to multiple growth
RT   inhibitory agents: possible relation to high bcl-2/bax ratio?";
RL   Cancer Lett. 161:27-34(2000).
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RX   PubMed=23868472; DOI=10.1038/ncomms3175; PMCID=PMC3759040;
RA   Johansson H.J., Sanchez B.C., Mundt F., Forshed J., Kovacs A.,
RA   Panizza E., Hultin-Rosenberg L., Lundgren B., Martens U., Mathe G.,
RA   Yakhini Z., Helou K., Krawiec K., Kanter L., Hjerpe A., Stal O.,
RA   Linderholm B.K., Lehtio J.;
RT   "Retinoic acid receptor alpha is associated with tamoxifen resistance
RT   in breast cancer.";
RL   Nat. Commun. 4:2175.1-2175.10(2013).
//