ID   MCF7/LCC1
AC   CVCL_DP50
SY   MCF-7/LCC-1; MCF-7/LCC1; LCC1
DR   cancercelllines; CVCL_DP50
DR   Wikidata; Q54904468
RX   PubMed=8324732;
RX   PubMed=8380254;
RX   PubMed=8380760;
CC   Population: Caucasian.
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C4194; Invasive breast carcinoma of no special type
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_DP49 ! MCF7/MIII
SX   Female
AG   69Y
CA   Cancer cell line
DT   Created: 13-07-16; Last updated: 05-10-23; Version: 12
//
RX   PubMed=8324732;
RA   Brunner N., Frandsen T.L., Holst-Hansen C., Bei M., Thompson E.W.,
RA   Wakeling A.E., Lippman M.E., Clarke R.;
RT   "MCF7/LCC2: a 4-hydroxytamoxifen resistant human breast cancer variant
RT   that retains sensitivity to the steroidal antiestrogen ICI 182,780.";
RL   Cancer Res. 53:3229-3232(1993).
//
RX   PubMed=8380254;
RA   Brunner N., Boulay V., Fojo A.T., Freter C.E., Lippman M.E., Clarke R.;
RT   "Acquisition of hormone-independent growth in MCF-7 cells is
RT   accompanied by increased expression of estrogen-regulated genes but
RT   without detectable DNA amplifications.";
RL   Cancer Res. 53:283-290(1993).
//
RX   PubMed=8380760; DOI=10.1007/BF00880062;
RA   Thompson E.W., Brunner N., Torri J., Johnson M.D., Boulay V.,
RA   Wright A., Lippman M.E., Steeg P.S., Clarke R.;
RT   "The invasive and metastatic properties of hormone-independent but
RT   hormone-responsive variants of MCF-7 human breast cancer cells.";
RL   Clin. Exp. Metastasis 11:15-26(1993).
//