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Cellosaurus Parks (CVCL_DN32)

[Text version]
Cell line name Parks
Synonyms PARKS
Accession CVCL_DN32
Resource Identification Initiative To cite this cell line use: Parks (RRID:CVCL_DN32)
Comments Problematic cell line: Partially contaminated. Some stocks of this cell line seemed to have been contaminated by a unknown human cell line (PubMed=21908323).
Part of: FACC canine tumor cell line panel.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00444.
Doubling time: 30 hours (PubMed=27257868).
Omics: Deep exome analysis.
Omics: Transcriptome analysis by microarray.
Sequence variations
  • Mutation; VGNC; VGNC:39068; CDKN1A; Simple; p.Asp33fs (c.97delG); Zygosity=Heterozygous (PubMed=31175136).
  • Mutation; VGNC; VGNC:54830; EIF1AX; Simple; p.Gly6Ser (c.16G>A); Zygosity=Heterozygous (PubMed=31175136).
  • Mutation; VGNC; VGNC:43120; MED12; Simple; p.Pro22Ser (c.64C>T); Zygosity=Homozygous (PubMed=31175136).
Disease Canine melanoma (NCIt: C120298)
Species of origin Canis lupus familiaris (Dog) (Canis familiaris) (NCBI Taxonomy: 9615)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): PubMed=27197945; PubMed=31175136

Markers:
Dog FHC2010231,239
Dog FHC2054156
Dog FHC2079275,279
Dog PEZ1115
Dog PEZ12270
Dog PEZ20176
Dog PEZ3119
Dog PEZ5111
Dog PEZ6183
Dog PEZ8240

Run an STR similarity search on this cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=21908323; DOI=10.1177/1040638711408064
O'Donoghue L.E., Rivest J.P., Duval D.L.
Polymerase chain reaction-based species verification and microsatellite analysis for canine cell line validation.
J. Vet. Diagn. Invest. 23:780-785(2011)

PubMed=27257868; DOI=10.1371/journal.pone.0156689; PMCID=PMC4892608
Maeda J., Froning C.E., Brents C.A., Rose B.J., Thamm D.H., Kato T.A.
Intrinsic radiosensitivity and cellular characterization of 27 canine cancer cell lines.
PLoS ONE 11:E0156689-E0156689(2016)

PubMed=27197945; DOI=10.1111/vco.12192; PMCID=PMC5656225
Fowles J.S., Dailey D.D., Gustafson D.L., Thamm D.H., Duval D.L.
The Flint Animal Cancer Center (FACC) canine tumour cell line panel: a resource for veterinary drug discovery, comparative oncology and translational medicine.
Vet. Comp. Oncol. 15:481-492(2017)

PubMed=31175136; DOI=10.1158/1535-7163.MCT-18-1346; PMCID=PMC6679748
Das S., Idate R., Cronise K.E., Gustafson D.L., Duval D.L.
Identifying candidate druggable targets in canine cancer cell lines using whole-exome sequencing.
Mol. Cancer Ther. 18:1460-1471(2019)

Cross-references
Encyclopedic resources Wikidata; Q54937580
Entry history
Entry creation13-Jul-2016
Last entry update19-Dec-2024
Version number13