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Cellosaurus PC-9/DR4 (CVCL_DI36)

[Text version]
Cell line name PC-9/DR4
Synonyms PC-9 DR4
Accession CVCL_DI36
Resource Identification Initiative To cite this cell line use: PC-9/DR4 (RRID:CVCL_DI36)
Comments Population: Chinese; Han and Japanese.
Selected for resistance to: ChEBI; CHEBI:132268; Dacomitinib (PF-00299804).
Selected for resistance to: ChEBI; CHEBI:49668; Gefitinib (ZD1839; Iressa).
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations
  • Mutation; HGNC; 3236; EGFR; Simple; p.Glu746_Ala750del (c.2235_2249del15); ClinVar=VCV000163343; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_DH34 (PC-9/GR4)
Sex of cell Male
Age at sampling 45Y
Category Cancer cell line
Publications

PubMed=20118985; DOI=10.1038/onc.2009.526; PMCID=PMC2859699
Ercan D., Zejnullahu K., Yonesaka K., Xiao Y., Capelletti M., Rogers A., Lifshits E., Brown A., Lee C., Christensen J.G., Kwiatkowski D.J., Engelman J.A., Janne P.A.
Amplification of EGFR T790M causes resistance to an irreversible EGFR inhibitor.
Oncogene 29:2346-2356(2010)

Cross-references
Cell line databases/resources cancercelllines; CVCL_DI36
Encyclopedic resources Wikidata; Q54938484
Gene expression databases GEO; GSM481170
Polymorphism and mutation databases Progenetix; CVCL_DI36
Entry history
Entry creation13-Jul-2016
Last entry update10-Sep-2024
Version number14