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Cellosaurus PC-9/DR1 (CVCL_DI33)

[Text version]
Cell line name PC-9/DR1
Synonyms PC-9 DR1
Accession CVCL_DI33
Resource Identification Initiative To cite this cell line use: PC-9/DR1 (RRID:CVCL_DI33)
Comments Population: Chinese; Han and Japanese.
Selected for resistance to: ChEBI; CHEBI:132268; Dacomitinib (PF-00299804).
Selected for resistance to: ChEBI; CHEBI:49668; Gefitinib (ZD1839; Iressa).
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations
  • Mutation; HGNC; 3236; EGFR; Simple; p.Glu746_Ala750del (c.2235_2249del15); ClinVar=VCV000163343; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_DH34 (PC-9/GR4)
Sex of cell Male
Age at sampling 45Y
Category Cancer cell line
Publications

PubMed=20118985; DOI=10.1038/onc.2009.526; PMCID=PMC2859699
Ercan D., Zejnullahu K., Yonesaka K., Xiao Y., Capelletti M., Rogers A., Lifshits E., Brown A., Lee C., Christensen J.G., Kwiatkowski D.J., Engelman J.A., Janne P.A.
Amplification of EGFR T790M causes resistance to an irreversible EGFR inhibitor.
Oncogene 29:2346-2356(2010)

Cross-references
Cell line databases/resources cancercelllines; CVCL_DI33
Encyclopedic resources Wikidata; Q54938481
Gene expression databases GEO; GSM481167
Polymorphism and mutation databases Progenetix; CVCL_DI33
Entry history
Entry creation13-Jul-2016
Last entry update10-Sep-2024
Version number14