ID   LAU-T50B
AC   CVCL_DI22
SY   LAU50_2
DR   cancercelllines; CVCL_DI22
DR   Cosmic; 1675357
DR   GEO; GSM566254
DR   GEO; GSM568794
DR   Progenetix; CVCL_DI22
DR   Wikidata; Q54901979
RX   PubMed=20862285;
RX   PubMed=21494657;
RX   PubMed=22197931;
CC   From: Ludwig Institute for Cancer Research, Lausanne Branch; Lausanne; Switzerland.
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (PubMed=20862285).
CC   Omics: Array-based CGH.
CC   Omics: CNV analysis.
CC   Omics: Deep exome analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
DI   NCIt; C3510; Cutaneous melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_S597 ! LAU-Me275
SX   Male
CA   Cancer cell line
DT   Created: 13-07-16; Last updated: 19-12-24; Version: 12
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RX   PubMed=20862285; DOI=10.1371/journal.pone.0012773; PMCID=PMC2940856;
RA   Caballero O.L., Zhao Q., Rimoldi D., Stevenson B.J., Svobodova S.,
RA   Devalle S., Rohrig U.F., Pagotto A., Michielin O., Speiser D.E.,
RA   Wolchok J.D., Liu C.-L., Pejovic T., Odunsi K., Brasseur F.,
RA   van den Eynde B.J., Old L.J., Lu X., Cebon J.S., Strausberg R.L.,
RA   Simpson A.J.G.;
RT   "Frequent MAGE mutations in human melanoma.";
RL   PLoS ONE 5:E12773-E12773(2010).
//
RX   PubMed=21494657; DOI=10.1371/journal.pone.0018369; PMCID=PMC3072964;
RA   Valsesia A., Rimoldi D., Martinet D., Ibberson M., Benaglio P.,
RA   Quadroni M., Waridel P., Gaillard M., Pidoux M., Rapin B., Rivolta C.,
RA   Xenarios I., Simpson A.J.G., Antonarakis S.E., Beckmann J.S.,
RA   Jongeneel C.V., Iseli C., Stevenson B.J.;
RT   "Network-guided analysis of genes with altered somatic copy number and
RT   gene expression reveals pathways commonly perturbed in metastatic
RT   melanoma.";
RL   PLoS ONE 6:E18369-E18369(2011).
//
RX   PubMed=22197931; DOI=10.1038/ng.1026;
RA   Nikolaev S.I., Rimoldi D., Iseli C., Valsesia A., Robyr D., Gehrig C.,
RA   Harshman K., Guipponi M., Bukach O.V., Zoete V., Michielin O.,
RA   Muehlethaler K., Speiser D.E., Beckmann J.S., Xenarios I.,
RA   Halazonetis T.D., Jongeneel C.V., Stevenson B.J., Antonarakis S.E.;
RT   "Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2
RT   mutations in melanoma.";
RL   Nat. Genet. 44:133-139(2011).
//