ID   LAU-T149D
AC   CVCL_DI21
SY   LAU149
DR   cancercelllines; CVCL_DI21
DR   Cosmic; 1675360
DR   GEO; GSM566251
DR   GEO; GSM568790
DR   Progenetix; CVCL_DI21
DR   Wikidata; Q54901972
RX   PubMed=20862285;
RX   PubMed=21494657;
RX   PubMed=22197931;
CC   From: Ludwig Institute for Cancer Research, Lausanne Branch; Lausanne; Switzerland.
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (PubMed=20862285).
CC   Omics: Array-based CGH.
CC   Omics: CNV analysis.
CC   Omics: Deep exome analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: Metastatic; Viscera; UBERON=UBERON_0002075.
DI   NCIt; C3510; Cutaneous melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_S596 ! LAU-Me260.LN
SX   Female
CA   Cancer cell line
DT   Created: 13-07-16; Last updated: 19-12-24; Version: 12
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RX   PubMed=20862285; DOI=10.1371/journal.pone.0012773; PMCID=PMC2940856;
RA   Caballero O.L., Zhao Q., Rimoldi D., Stevenson B.J., Svobodova S.,
RA   Devalle S., Rohrig U.F., Pagotto A., Michielin O., Speiser D.E.,
RA   Wolchok J.D., Liu C.-L., Pejovic T., Odunsi K., Brasseur F.,
RA   van den Eynde B.J., Old L.J., Lu X., Cebon J.S., Strausberg R.L.,
RA   Simpson A.J.G.;
RT   "Frequent MAGE mutations in human melanoma.";
RL   PLoS ONE 5:E12773-E12773(2010).
//
RX   PubMed=21494657; DOI=10.1371/journal.pone.0018369; PMCID=PMC3072964;
RA   Valsesia A., Rimoldi D., Martinet D., Ibberson M., Benaglio P.,
RA   Quadroni M., Waridel P., Gaillard M., Pidoux M., Rapin B., Rivolta C.,
RA   Xenarios I., Simpson A.J.G., Antonarakis S.E., Beckmann J.S.,
RA   Jongeneel C.V., Iseli C., Stevenson B.J.;
RT   "Network-guided analysis of genes with altered somatic copy number and
RT   gene expression reveals pathways commonly perturbed in metastatic
RT   melanoma.";
RL   PLoS ONE 6:E18369-E18369(2011).
//
RX   PubMed=22197931; DOI=10.1038/ng.1026;
RA   Nikolaev S.I., Rimoldi D., Iseli C., Valsesia A., Robyr D., Gehrig C.,
RA   Harshman K., Guipponi M., Bukach O.V., Zoete V., Michielin O.,
RA   Muehlethaler K., Speiser D.E., Beckmann J.S., Xenarios I.,
RA   Halazonetis T.D., Jongeneel C.V., Stevenson B.J., Antonarakis S.E.;
RT   "Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2
RT   mutations in melanoma.";
RL   Nat. Genet. 44:133-139(2011).
//