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Cellosaurus HCC827 PFR4 (CVCL_DH94)

[Text version]
Cell line name HCC827 PFR4
Synonyms HCC827 PFR-4
Accession CVCL_DH94
Resource Identification Initiative To cite this cell line use: HCC827 PFR4 (RRID:CVCL_DH94)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_132268; Dacomitinib (PF-00299804).
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Glu746_Ala750del (c.2236_2250del15); ClinVar=VCV000177620; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Val218del (c.646_648GTG[2]) (c.652_654delGTG); ClinVar=VCV000634761; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2063 (HCC827)
Sex of cell Female
Age at sampling 39Y
Category Cancer cell line
Publications

PubMed=20129249; DOI=10.1016/j.ccr.2009.11.022; PMCID=PMC2980857
Schrock A.B., Zejnullahu K., Wu Y.-L., Song Y., Dias-Santagata D., Lifshits E., Toschi L., Rogers A., Mok T., Sequist L.V., Lindeman N.I., Murphy C., Akhavanfard S., Yeap B.Y., Xiao Y., Capelletti M., Iafrate A.J., Lee C., Christensen J.G., Engelman J.A., Janne P.A.
Preexistence and clonal selection of MET amplification in EGFR mutant NSCLC.
Cancer Cell 17:77-88(2010)

Cross-references
Cell line databases/resources cancercelllines; CVCL_DH94
Encyclopedic resources Wikidata; Q54881797
Gene expression databases GEO; GSM466328
Polymorphism and mutation databases Progenetix; CVCL_DH94
Entry history
Entry creation13-Jul-2016
Last entry update19-Dec-2024
Version number13