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Cellosaurus MDA-MB-468GFP (CVCL_DH83)

[Text version]
Cell line name MDA-MB-468GFP
Synonyms 468GFP
Accession CVCL_DH83
Resource Identification Initiative To cite this cell line use: MDA-MB-468GFP (RRID:CVCL_DH83)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Population: African American.
Genetic integration: Method=Transfection/transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
Omics: CNV analysis.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; 9588; PTEN; Simple; c.253+1G>T; ClinVar=VCV000189475; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
  • Mutation; HGNC; 9884; RB1; Simple; c.265_2787del2523; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0419 (MDA-MB-468)
Children:
CVCL_M372 (MDA-MB-468LN)
Sex of cell Female
Age at sampling 51Y
Category Cancer cell line
Publications

PubMed=16170671; DOI=10.1007/s10585-005-0745-1
Vantyghem S.A., Allan A.L., Postenka C.O., Al-Katib W., Keeney M., Tuck A.B., Chambers A.F.
A new model for lymphatic metastasis: development of a variant of the MDA-MB-468 human breast cancer cell line that aggressively metastasizes to lymph nodes.
Clin. Exp. Metastasis 22:351-361(2005)

PubMed=20084286; DOI=10.1371/journal.pone.0008665; PMCID=PMC2801616
Andrews J.D., Kennette W., Pilon J., Hodgson A., Tuck A.B., Chambers A.F., Rodenhiser D.I.
Multi-platform whole-genome microarray analyses refine the epigenetic signature of breast cancer metastasis with gene expression and copy number.
PLoS ONE 5:E8665-E8665(2010)

Cross-references
Cell line databases/resources cancercelllines; CVCL_DH83
Encyclopedic resources Wikidata; Q54904646
Gene expression databases GEO; GSM390975
GEO; GSM390978
Polymorphism and mutation databases Progenetix; CVCL_DH83
Entry history
Entry creation13-Jul-2016
Last entry update10-Sep-2024
Version number16