ID   MGH119-R
AC   CVCL_DH48
SY   MGH119-GR
DR   GEO; GSM1568546
DR   Wikidata; Q54905472
RX   PubMed=25758528;
CC   Selected for resistance to: ChEBI; CHEBI_49668; Gefitinib (ZD1839; Iressa).
CC   Sequence variation: Mutation; HGNC; HGNC:3236; EGFR; Unexplicit; Ex19del; Zygosity=Unspecified (PubMed=25758528).
CC   Sequence variation: Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Thr790Met (c.2369C>T); ClinVar=VCV000016613; Zygosity=Unspecified (PubMed=25758528).
CC   Omics: Transcriptome analysis by microarray.
DI   NCIt; C2926; Lung non-small cell carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_DH47 ! MGH119
SX   Sex unspecified
AG   Age unspecified
CA   Cancer cell line
DT   Created: 13-07-16; Last updated: 19-12-24; Version: 7
//
RX   PubMed=25758528; DOI=10.1038/ncomms7377; PMCID=PMC4357281;
RA   Niederst M.J., Sequist L.V., Poirier J.T., Mermel C.H.,
RA   Lockerman E.L., Garcia A.R., Katayama R., Costa C., Ross K.N.,
RA   Moran T., Howe E., Fulton L.E., Mulvey H.E., Bernardo L.A.,
RA   Mohamoud F., Miyoshi N., VanderLaan P.A., Costa D.B., Janne P.A.,
RA   Borger D.R., Ramaswamy S., Shioda T., Iafrate A.J., Getz G.,
RA   Rudin C.M., Mino-Kenudson M., Engelman J.A.;
RT   "RB loss in resistant EGFR mutant lung adenocarcinomas that transform
RT   to small-cell lung cancer.";
RL   Nat. Commun. 6:6377.1-6377.10(2015).
//