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Cellosaurus SUM149-Luc/MA2 (CVCL_DH46)

[Text version]
Cell line name SUM149-Luc/MA2
Synonyms MA2
Accession CVCL_DH46
Resource Identification Initiative To cite this cell line use: SUM149-Luc/MA2 (RRID:CVCL_DH46)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P08659; Firefly luciferase.
Derived from site: In situ; Breast; UBERON=UBERON_0000310.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1100; BRCA1; Simple; p.Pro724Leufs*12 (c.2169delT) (p.Asn723fs*13) (2288delT); Zygosity=Hemizygous (from parent cell line).
  • Mutation; HGNC; HGNC:3373; EP300; Simple; c.4025+26_4025+30 (c.5224+28del3); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Met237Ile (c.711G>A); ClinVar=VCV000142714; Zygosity=Unspecified (from parent cell line).
Disease Breast inflammatory carcinoma (NCIt: C4001)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_DH44 (SUM149-Luc)
Sex of cell Female
Age at sampling 40Y
Category Cancer cell line
Publications

PubMed=25279830; DOI=10.1371/journal.pone.0109487; PMCID=PMC4184880
Singh B., Shamsnia A., Raythatha M.R., Milligan R.D., Cady A.M., Madan S., Lucci A.
Highly adaptable triple-negative breast cancer cells as a functional model for testing anticancer agents.
PLoS ONE 9:E109487-E109487(2014)

Cross-references
Cell line databases/resources cancercelllines; CVCL_DH46
Encyclopedic resources Wikidata; Q54970831
Gene expression databases GEO; GSM1463861
GEO; GSM1463864
Entry history
Entry creation13-Jul-2016
Last entry update19-Dec-2024
Version number16