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Cellosaurus OVCAR3-533533-R6 (CVCL_DH40)

[Text version]
Cell line name OVCAR3-533533-R6
Synonyms 533533-R6
Accession CVCL_DH40
Resource Identification Initiative To cite this cell line use: OVCAR3-533533-R6 (RRID:CVCL_DH40)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:132239; PHA-533533.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; 8979; PIK3R1; Simple; c.1746-2A>T; Zygosity=Heterozygous; Note=Splice acceptor mutation (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
Disease High grade ovarian serous adenocarcinoma (NCIt: C105555)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0465 (OVCAR-3)
Sex of cell Female
Age at sampling 60Y
Category Cancer cell line

PubMed=24004674; DOI=10.1158/1078-0432.CCR-13-1337
Etemadmoghadam D., Au-Yeung G., Wall M., Mitchell C., Kansara M., Loehrer E., Batzios C., George J., Ftouni S., Weir B.A., Carter S., Gresshoff I., Mileshkin L., Rischin D., Hahn W.C., Waring P.M., Getz G., Cullinane C., Campbell L.J., Bowtell D.D.L.
Resistance to CDK2 inhibitors is associated with selection of polyploid cells in CCNE1-amplified ovarian cancer.
Clin. Cancer Res. 19:5960-5971(2013)

Encyclopedic resources Wikidata; Q54937021
Gene expression databases GEO; GSM1186820
GEO; GSM1186825
GEO; GSM1186831
Polymorphism and mutation databases Progenetix; CVCL_DH40
Entry history
Entry creation13-Jul-2016
Last entry update29-Jun-2023
Version number11