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Cellosaurus PC-9/WZR12 (CVCL_DG33)

[Text version]
Cell line name PC-9/WZR12
Synonyms WZR12
Accession CVCL_DG33
Resource Identification Initiative To cite this cell line use: PC-9/WZR12 (RRID:CVCL_DG33)
Comments Population: Chinese; Han and Japanese.
Selected for resistance to: ChEBI; CHEBI:49668; Gefitinib (ZD1839; Iressa).
Selected for resistance to: ChEBI; CHEBI:61400; WZ4002.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations
  • Mutation; HGNC; 3236; EGFR; Simple; p.Glu746_Ala750del (c.2235_2249del15); ClinVar=VCV000163343; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_DH34 (PC-9/GR4)
Sex of cell Male
Age at sampling 45Y
Category Cancer cell line
Publications

PubMed=22961667; DOI=10.1158/2159-8290.CD-12-0103; PMCID=PMC3477553
Ercan D., Xu C.-X., Yanagita M., Monast C.S., Pratilas C.A., Montero J., Butaney M., Shimamura T., Sholl L.M., Ivanova E.V., Tadi M., Rogers A., Repellin C., Capelletti M., Maertens O., Goetz E.M., Letai A.G., Garraway L.A., Lazzara M.J., Rosen N., Gray N.S., Wong K.-K., Janne P.A.
Reactivation of ERK signaling causes resistance to EGFR kinase inhibitors.
Cancer Discov. 2:934-947(2012)

Cross-references
Cell line databases/resources cancercelllines; CVCL_DG33
Encyclopedic resources Wikidata; Q54938508
Gene expression databases GEO; GSM925742
Polymorphism and mutation databases Progenetix; CVCL_DG33
Entry history
Entry creation13-Jul-2016
Last entry update10-Sep-2024
Version number14