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Cellosaurus H1975/WR (CVCL_DG25)

[Text version]
Cell line name H1975/WR
Accession CVCL_DG25
Resource Identification Initiative To cite this cell line use: H1975/WR (RRID:CVCL_DG25)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:61400; WZ4002.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; 3236; EGFR; Simple; p.Thr790Met (c.2369C>T); ClinVar=VCV000016613; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 3236; EGFR; Simple; p.Leu858Arg (c.2573T>G); ClinVar=VCV000016609; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Gly118Asp (c.353G>A); ClinVar=VCV000156446; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1511 (NCI-H1975)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=26980747; DOI=10.18632/oncotarget.8013; PMCID=PMC5008340
Park J.H., Choi Y.J., Kim S.Y., Lee J.-E., Sung K.J., Park S., Kim W.S., Song J.S., Choi C.-M., Sung Y.H., Rho J.K., Lee J.C.
Activation of the IGF1R pathway potentially mediates acquired resistance to mutant-selective 3rd-generation EGF receptor tyrosine kinase inhibitors in advanced non-small cell lung cancer.
Oncotarget 7:22005-22015(2016)

Cross-references
Cell line databases/resources cancercelllines; CVCL_DG25
Encyclopedic resources Wikidata; Q54871980
Entry history
Entry creation13-Jul-2016
Last entry update05-Oct-2023
Version number10