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Cellosaurus MLEL1.1c1 (CVCL_DC34)

[Text version]
Cell line name MLEL1.1c1
Accession CVCL_DC34
Resource Identification Initiative To cite this cell line use: MLEL1.1c1 (RRID:CVCL_DC34)
Comments Biotechnology: Cell line developed for CALUX (Chemically Activated LUciferase eXpression) bioassay. CALUX is used for rapid screening of samples for the presence of dioxin/TCDD-like compounds and AhR agonists/antagonists.
Characteristics: Acts through the activation of a luciferase reporter gene under the control of dioxin-response elements (DREs).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P08659; Firefly luciferase.
Disease Hepatocellular carcinoma of the mouse (NCIt: C38756)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C3H/HeN.
Hierarchy Parent: CVCL_DC33 (MLE/BV)
Category Cancer cell line
Publications

PubMed=8812265; DOI=10.1006/faat.1996.0056
Garrison P.M., Tullis K., Aarts J.M.M.J.G., Brouwer A., Giesy J.P., Denison M.S.
Species-specific recombinant cell lines as bioassay systems for the detection of 2,3,7,8-tetrachlorodibenzo-p-dioxin-like chemicals.
Fundam. Appl. Toxicol. 30:194-203(1996)

Patent=US5854010
Denison M.S., Brouwer A., Clark G.C.
Bioassay for detecting 2,3,7,8-tetrachlorodibenzo-para-dioxin and TCDD-like compounds and novel recombinant cell line useful therefor.
Patent number US5854010, 29-Dec-1998

Cross-references
Encyclopedic resources Wikidata; Q54905971
Entry history
Entry creation13-Jul-2016
Last entry update10-Sep-2024
Version number7