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Cellosaurus HG2L1.1c3 (CVCL_DC29)

[Text version]
Cell line name HG2L1.1c3
Accession CVCL_DC29
Resource Identification Initiative To cite this cell line use: HG2L1.1c3 (RRID:CVCL_DC29)
Comments Population: Caucasian.
Biotechnology: Cell line developed for CALUX (Chemically Activated LUciferase eXpression) bioassay. CALUX is used for rapid screening of samples for the presence of dioxin/TCDD-like compounds and AhR agonists/antagonists.
Characteristics: Acts through the activation of a luciferase reporter gene under the control of dioxin-response elements (DREs).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P08659; Firefly luciferase.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Hepatoblastoma (NCIt: C3728)
Hepatoblastoma (ORDO: Orphanet_449)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0027 (Hep-G2)
Sex of cell Male
Age at sampling 15Y
Category Cancer cell line
Publications

PubMed=8812265; DOI=10.1006/faat.1996.0056
Garrison P.M., Tullis K., Aarts J.M.M.J.G., Brouwer A., Giesy J.P., Denison M.S.
Species-specific recombinant cell lines as bioassay systems for the detection of 2,3,7,8-tetrachlorodibenzo-p-dioxin-like chemicals.
Fundam. Appl. Toxicol. 30:194-203(1996)

Patent=US5854010
Denison M.S., Brouwer A., Clark G.C.
Bioassay for detecting 2,3,7,8-tetrachlorodibenzo-para-dioxin and TCDD-like compounds and novel recombinant cell line useful therefor.
Patent number US5854010, 29-Dec-1998

Cross-references
Cell line databases/resources cancercelllines; CVCL_DC29
Encyclopedic resources Wikidata; Q54885924
Entry history
Entry creation13-Jul-2016
Last entry update19-Dec-2024
Version number18