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Cellosaurus H1L7.5c3 (CVCL_DC25)

[Text version]
Cell line name H1L7.5c3
Accession CVCL_DC25
Resource Identification Initiative To cite this cell line use: H1L7.5c3 (RRID:CVCL_DC25)
Comments Biotechnology: Cell line developed for CALUX (Chemically Activated LUciferase eXpression) bioassay. CALUX is used for rapid screening of samples for the presence of dioxin/TCDD-like compounds and AhR agonists/antagonists.
Characteristics: Acts through the activation of a luciferase reporter gene under the control of dioxin-response elements (DREs).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P08659; Firefly luciferase.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Disease Hepatocellular carcinoma of the mouse (NCIt: C38756)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C57L.
Hierarchy Parent: CVCL_0328 (Hepa-1c1c7)
Sex of cell Female
Category Cancer cell line
Publications

PubMed=26366531; DOI=10.1021/acs.est.5b02906; PMCID=PMC4772899
Brennan J.C., He G.-C., Tsutsumi T., Zhao J., Wirth E., Fulton M.H., Denison M.S.
Development of species-specific Ah receptor-responsive third generation CALUX cell lines with enhanced responsiveness and improved detection limits.
Environ. Sci. Technol. 49:11903-11912(2015)

Cross-references
Encyclopedic resources Wikidata; Q54871991
Entry history
Entry creation13-Jul-2016
Last entry update10-Sep-2024
Version number10