Cellosaurus cell line H1L1.1c2 (CVCL

Cellosaurus H1L1.1c2 (CVCL_DC20)

Cross-references
Cell line name	H1L1.1c2
Synonyms	H1L1.1
Accession	CVCL_DC20
Resource Identification Initiative	To cite this cell line use: H1L1.1c2 (RRID:CVCL_DC20)
Comments	Group: Patented cell line. Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-12286. Biotechnology: Cell line developed for CALUX (Chemically Activated LUciferase eXpression) bioassay. CALUX is used for rapid screening of samples for the presence of dioxin/TCDD-like compounds and AhR agonists/antagonists. Characteristics: Acts through the activation of a luciferase reporter gene under the control of dioxin-response elements (DREs). Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P08659; Firefly luciferase. Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Disease	Hepatocellular carcinoma of the mouse (NCIt: C38756)
Species of origin	Mus musculus (Mouse) (NCBI Taxonomy: 10090) Breed/subspecies: C57L/J.
Hierarchy	Parent: CVCL_0328 (Hepa-1c1c7)
Sex of cell	Female
Category	Cancer cell line
Publications	PubMed=8812265; DOI=10.1006/faat.1996.0056 Garrison P.M., Tullis K., Aarts J.M.M.J.G., Brouwer A., Giesy J.P., Denison M.S. Species-specific recombinant cell lines as bioassay systems for the detection of 2,3,7,8-tetrachlorodibenzo-p-dioxin-like chemicals. Fundam. Appl. Toxicol. 30:194-203(1996) Patent=US5854010 Denison M.S., Brouwer A., Clark G.C. Bioassay for detecting 2,3,7,8-tetrachlorodibenzo-para-dioxin and TCDD-like compounds and novel recombinant cell line useful therefor. Patent number US5854010, 29-Dec-1998 PubMed=15096657; DOI=10.1002/biof.5520200102 Han D., Nagy S.R., Denison M.S. Comparison of recombinant cell bioassays for the detection of Ah receptor agonists. BioFactors 20:11-22(2004) PubMed=18969542; DOI=10.1016/j.talanta.2004.05.032 Denison M.S., Zhao B., Baston D.S., Clark G.C., Murata H., Han D. Recombinant cell bioassay systems for the detection and relative quantitation of halogenated dioxins and related chemicals. Talanta 63:1123-1133(2004) PubMed=21394221; DOI=10.1007/s11426-010-0142-8; PMCID=PMC3049243 Zhao B., Baston D.S., Khan E., Sorrentino C., Denison M.S. Enhancing the response of CALUX and CAFLUX cell bioassays for quantitative detection of dioxin-like compounds. Sci. China Chem. 53:1010-1016(2010)
Encyclopedic resources	Wikidata; Q54871986
Entry history
Entry creation	13-Jul-2016
Last entry update	19-Dec-2024
Version number	12