ID   G16L1.1c8
AC   CVCL_DC17
DR   Wikidata; Q54835369
RX   Patent=US5854010;
RX   PubMed=8812265;
RX   PubMed=18969542;
RX   PubMed=21394221;
RX   PubMed=26366531;
CC   Biotechnology: Cell line developed for CALUX (Chemically Activated LUciferase eXpression) bioassay. CALUX is used for rapid screening of samples for the presence of dioxin/TCDD-like compounds and AhR agonists/antagonists.
CC   Characteristics: Acts through the activation of a luciferase reporter gene under the control of dioxin-response elements (DREs).
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P08659; Firefly luciferase.
CC   Transformant: ChEBI; CHEBI_50102; N-methyl-N-nitrosourea (NMU).
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
DI   NCIt; C134563; Guinea pig colon adenocarcinoma
OX   NCBI_TaxID=10141; ! Cavia porcellus (Guinea pig)
HI   CVCL_3463 ! GPC-16
SX   Female
AG   Adult
CA   Cancer cell line
DT   Created: 13-07-16; Last updated: 19-12-24; Version: 11
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RX   Patent=US5854010;
RA   Denison M.S., Brouwer A., Clark G.C.;
RT   "Bioassay for detecting 2,3,7,8-tetrachlorodibenzo-para-dioxin and
RT   TCDD-like compounds and novel recombinant cell line useful therefor.";
RL   Patent number US5854010, 29-Dec-1998.
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RX   PubMed=8812265; DOI=10.1006/faat.1996.0056;
RA   Garrison P.M., Tullis K., Aarts J.M.M.J.G., Brouwer A., Giesy J.P.,
RA   Denison M.S.;
RT   "Species-specific recombinant cell lines as bioassay systems for the
RT   detection of 2,3,7,8-tetrachlorodibenzo-p-dioxin-like chemicals.";
RL   Fundam. Appl. Toxicol. 30:194-203(1996).
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RX   PubMed=18969542; DOI=10.1016/j.talanta.2004.05.032;
RA   Denison M.S., Zhao B., Baston D.S., Clark G.C., Murata H., Han D.;
RT   "Recombinant cell bioassay systems for the detection and relative
RT   quantitation of halogenated dioxins and related chemicals.";
RL   Talanta 63:1123-1133(2004).
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RX   PubMed=21394221; DOI=10.1007/s11426-010-0142-8; PMCID=PMC3049243;
RA   Zhao B., Baston D.S., Khan E., Sorrentino C., Denison M.S.;
RT   "Enhancing the response of CALUX and CAFLUX cell bioassays for
RT   quantitative detection of dioxin-like compounds.";
RL   Sci. China Chem. 53:1010-1016(2010).
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RX   PubMed=26366531; DOI=10.1021/acs.est.5b02906; PMCID=PMC4772899;
RA   Brennan J.C., He G.-C., Tsutsumi T., Zhao J., Wirth E., Fulton M.H.,
RA   Denison M.S.;
RT   "Development of species-specific Ah receptor-responsive third
RT   generation CALUX cell lines with enhanced responsiveness and improved
RT   detection limits.";
RL   Environ. Sci. Technol. 49:11903-11912(2015).
//