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Cellosaurus JJ012-TS4 (CVCL_D901)

[Text version]
Cell line name JJ012-TS4
Accession CVCL_D901
Resource Identification Initiative To cite this cell line use: JJ012-TS4 (RRID:CVCL_D901)
Comments Genetic integration: Method=Transfection/transduction; Gene=HGNC; 220; ADAMTS4.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 5382; IDH1; Simple; p.Arg132Gly (c.394C>G); ClinVar=VCV000375892; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Gly199Val (c.596G>T); ClinVar=VCV000451799; Zygosity=Unspecified (from parent cell line).
Disease Primary central chondrosarcoma (NCIt: C7155)
Chondrosarcoma (ORDO: Orphanet_55880)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_D605 (JJ012)
Sex of cell Male
Age at sampling 39Y
Category Cancer cell line
Publications

PubMed=11796708; DOI=10.1074/jbc.M107443200
Gao G., Westling J., Thompson V.P., Howell T.D., Gottschall P.E., Sandy J.D.
Activation of the proteolytic activity of ADAMTS4 (aggrecanase-1) by C-terminal truncation.
J. Biol. Chem. 277:11034-11041(2002)

PubMed=14701864; DOI=10.1074/jbc.M312100200
Gao G., Plaas A., Thompson V.P., Jin S., Zuo F.-R., Sandy J.D.
ADAMTS4 (aggrecanase-1) activation on the cell surface involves C-terminal cleavage by glycosylphosphatidyl inositol-anchored membrane type 4-matrix metalloproteinase and binding of the activated proteinase to chondroitin sulfate and heparan sulfate on syndecan-1.
J. Biol. Chem. 279:10042-10051(2004)

Cross-references
Cell line databases/resources cancercelllines; CVCL_D901
Anatomy/cell type resources BTO; BTO:0003043
Encyclopedic resources Wikidata; Q54898951
Entry history
Entry creation22-Oct-2012
Last entry update10-Sep-2024
Version number18