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Cellosaurus HEI-OC1 (CVCL_D899)

[Text version]
Cell line name HEI-OC1
Synonyms HEIOC1; House Ear Institute-Organ of Corti 1
Accession CVCL_D899
Resource Identification Initiative To cite this cell line use: HEI-OC1 (RRID:CVCL_D899)
Comments Characteristics: Growth at the permissive (33 Celsius) temperature results in dedifferentiation of the cells and accelerated proliferation. At the restrictive temperature (39 Celsius) cell proliferation halts in about 48h.
Genetic integration: Method=Transgenic mouse; Gene=UniProtKB; P03070; SV40 large T antigen.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=tsA58).
Derived from site: In situ; Ear, inner ear, cochlea, organ of Corti; UBERON=UBERON_0002227.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: (CBA/Ca x C57BL/10)Tg(H2Kb-tsA58) Immortomouse.
Sex of cell Sex unspecified
Age at sampling 7D
Category Conditionally immortalized cell line
Web pages http://www.molmeth.org/protocol/culturing-hei-oc1
Publications

PubMed=12811000; DOI=10.1159/000071059
Kalinec G.M., Webster P., Lim D.J., Kalinec F.
A cochlear cell line as an in vitro system for drug ototoxicity screening.
Audiol. Neurootol. 8:177-189(2003)

PubMed=26854618; DOI=10.1016/j.heares.2016.02.001
Park C., Thein P., Kalinec G.M., Kalinec F.
HEI-OC1 cells as a model for investigating prestin function.
Hear. Res. 335:9-17(2016)

PubMed=26930622; DOI=10.1016/j.heares.2016.02.019
Kalinec G.M., Thein P., Park C., Kalinec F.
HEI-OC1 cells as a model for investigating drug cytotoxicity.
Hear. Res. 335:105-117(2016)

Cross-references
Anatomy/cell type resources BTO; BTO_0004862
Encyclopedic resources Wikidata; Q27653205
Entry history
Entry creation22-Oct-2012
Last entry update19-Dec-2024
Version number12