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Cellosaurus 11-18-ER2-1 (CVCL_D857)

[Text version]
Cell line name 11-18-ER2-1
Synonyms 11-18/ER2-1
Accession CVCL_D857
Resource Identification Initiative To cite this cell line use: 11-18-ER2-1 (RRID:CVCL_D857)
Comments Population: Japanese and Micro.
Selected for resistance to: ChEBI; CHEBI_114785; Erlotinib.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Leu858Arg (c.2573T>G); ClinVar=VCV000016609; Zygosity=Heterozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_6659 (11-18)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=22815900; DOI=10.1371/journal.pone.0041017; PMCID=PMC3398867
Tabara K., Kanda R., Sonoda K., Kubo T., Murakami Y., Kawahara A., Azuma K., Abe H., Kage M., Yoshinaga A., Tahira T., Hayashi K., Arao T., Nishio K., Rosell R., Kuwano M., Ono M.
Loss of activating EGFR mutant gene contributes to acquired resistance to EGFR tyrosine kinase inhibitors in lung cancer cells.
PLoS ONE 7:E41017-E41017(2012)

Cross-references
Cell line databases/resources cancercelllines; CVCL_D857
Encyclopedic resources Wikidata; Q54554909
Polymorphism and mutation databases Cosmic; 1731374
Entry history
Entry creation22-Oct-2012
Last entry update19-Dec-2024
Version number17