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Cellosaurus MM253-12M (CVCL_D849)

[Text version]
Cell line name MM253-12M
Accession CVCL_D849
Resource Identification Initiative To cite this cell line use: MM253-12M (RRID:CVCL_D849)
Comments Selected for resistance to: ChEBI; CHEBI:28876; Melphalan (L-phenylalanine mustard; LPAM; Alkeran).
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000027.
Sequence variations
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (from parent cell line).
Disease Amelanotic melanoma (NCIt: C3802)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2604 (MM253)
Sex of cell Male
Age at sampling 46Y
Category Cancer cell line
Publications

PubMed=669848; DOI=10.1002/ijc.2910210407
Parsons P.G., Morrison L.E.
Melphalan-induced chromosome damage in sensitive and resistant human melanoma cell lines.
Int. J. Cancer 21:438-443(1978)

PubMed=6163526
Parsons P.G., Carter F.B., Morrison L.E., Dunne R.M.
Mechanism of melphalan resistance developed in vitro in human melanoma cells.
Cancer Res. 41:1525-1534(1981)

PubMed=7060019
Parsons P.G., Smellie S.G., Morrison L.E., Hayward I.P.
Properties of human melanoma cells resistant to 5-(3',3'-dimethyl-1-triazeno)imidazole-4-carboxamide and other methylating agents.
Cancer Res. 42:1454-1461(1982)

Cross-references
Cell line databases/resources cancercelllines; CVCL_D849
Encyclopedic resources Wikidata; Q54906085
Entry history
Entry creation22-Oct-2012
Last entry update05-Oct-2023
Version number15