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Cellosaurus NZM003 (CVCL_D828)

[Text version]
Cell line name NZM003
Synonyms NZM03; NZM3
Accession CVCL_D828
Resource Identification Initiative To cite this cell line use: NZM003 (RRID:CVCL_D828)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Doubling time: 40.8 hours (CelloPub=CLPUB00227); 44-48 hours (CBA=CBA-1392).
Omics: Deep exome analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Caution: The results of the Sequenom MassARRAY used in PubMed=32567790 contradicts the whole exome sequencing data for BRAF and indicates a p.Val600Lys (c.1798_1799delGTinsAA) variant.
Derived from site: Metastatic; Cervical lymph node; UBERON=UBERON_0002429.
Sequence variations
HLA typing Source: PubMed=32567790
Class I
HLA-AA*01:01,02:01
HLA-BB*08:01,27:05
HLA-CC*02:02,07:01
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 69Y
Category Cancer cell line
STR profile Source(s): CBA; DepMap; PubMed=32567790

Markers:
AmelogeninX,Y
CSF1PO11
D2S133822,24
D3S135817
D5S81812
D7S8209,10 (CBA; DepMap)
10 (PubMed=32567790)
D8S117913,14
D13S31712
D16S53911,13
D18S5112,18
D19S43312,15
D21S1129,30.2
FGA20,22
Penta D9
Penta E10,14
TH019
TPOX8
vWA15,17

Run an STR similarity search on this cell line
Publications

PubMed=7999427; DOI=10.1016/0959-8049(94)90188-0
Marshall E.S., Matthews J.H.L., Shaw J.H.F., Nixon J., Tumewu P., Finlay G.J., Holdaway K.M., Baguley B.C.
Radiosensitivity of new and established human melanoma cell lines: comparison of [3H]thymidine incorporation and soft agar clonogenic assays.
Eur. J. Cancer 30:1370-1376(1994)

PubMed=11216673; DOI=10.3727/096504001108747620
Parmar J., Marshall E.S., Charters G.A., Holdaway K.M., Shelling A.N., Baguley B.C.
Radiation-induced cell cycle delays and p53 status of early passage melanoma cell lines.
Oncol. Res. 12:149-155(2000)

PubMed=20041153; DOI=10.1371/journal.pone.0008461
Jeffs A.R., Glover A.C., Slobbe L.J., Wang L., He S.-J., Hazlett J.A., Awasthi A., Woolley A.G., Marshall E.S., Joseph W.R., Print C.G., Baguley B.C., Eccles M.R.
A gene expression signature of invasive potential in metastatic melanoma cells.
PLoS ONE 4:E8461-E8461(2009)

CLPUB00227
Daukste L.
Mathematical modelling of cancer cell population dynamics.
Thesis PhD (2012), University of Canterbury, New Zealand

PubMed=22475322; DOI=10.1186/1471-2407-12-141
Kim J.E., Stones C.J., Joseph W.R., Leung E.Y., Finlay G.J., Shelling A.N., Phillips W.A., Shepherd P.R., Baguley B.C.
Comparison of growth factor signalling pathway utilisation in cultured normal melanocytes and melanoma cell lines.
BMC Cancer 12:141.1-141.10(2012)

PubMed=23658559; DOI=10.3389/fgene.2013.00066
Stones C.J., Kim J.E., Joseph W.R., Leung E.Y., Marshall E.S., Finlay G.J., Shelling A.N., Baguley B.C.
Comparison of responses of human melanoma cell lines to MEK and BRAF inhibitors.
Front. Genet. 4:66.1-66.6(2013)

PubMed=23755070; DOI=10.3389/fgene.2013.00097
Kim J.E., Leung E.Y., Baguley B.C., Finlay G.J.
Heterogeneity of expression of epithelial-mesenchymal transition markers in melanocytes and melanoma cell lines.
Front. Genet. 4:97.1-97.8(2013)

PubMed=24455489; DOI=10.3389/fonc.2013.00333
D'mello S.A.N., Flanagan J.U., Green T.N., Leung E.Y., Askarian-Amiri M.E., Joseph W.R., McCrystal M.R., Isaacs R.J., Shaw J.H.F., Furneaux C.E., During M.J., Finlay G.J., Baguley B.C., Kalev-Zylinska M.L.
Evidence that GRIN2A mutations in melanoma correlate with decreased survival.
Front. Oncol. 3:333.1-333.9(2014)

PubMed=32567790; DOI=10.1111/pcmr.12908
Tran K.B., Gimenez G., Tsai P., Kolekar S., Rodger E.J., Chatterjee A., Jabed A., Shih J.-H., Joseph W.R., Marshall E.S., Wang Q., Print C.G., Eccles M.R., Baguley B.C., Shepherd P.R.
Genomic and signalling pathway characterization of the NZM panel of melanoma cell lines: a valuable model for studying the impact of genetic diversity in melanoma.
Pigment Cell Melanoma Res. 34:136-143(2021)

Cross-references
Cell line collections (Providers) CBA; CBA-1392
Cell line databases/resources cancercelllines; CVCL_D828
DepMap; ACH-001982
Biological sample resources BioSample; SAMN07624443
BioSample; SAMN14558314
Encyclopedic resources Wikidata; Q54931561
Polymorphism and mutation databases Cosmic; 1660299
Cosmic; 2007644
Cosmic; 2406331
Entry history
Entry creation22-Oct-2012
Last entry update05-Oct-2023
Version number20