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Cellosaurus NZM012 (CVCL_D818)

[Text version]
Cell line name NZM012
Synonyms NZM12
Accession CVCL_D818
Resource Identification Initiative To cite this cell line use: NZM012 (RRID:CVCL_D818)
Comments Doubling time: 25.9 hours (CelloPub=CLPUB00227); 40-42 hours (CBA=CBA-1383).
Omics: Deep exome analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: Metastatic; Small intestine; UBERON=UBERON_0002108.
Sequence variations
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=23755070; PubMed=32567790).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (PubMed=32567790).
HLA typing Source: PubMed=32567790
Class I
HLA-AA*02:01,32:01
HLA-BB*44:02,44:02
HLA-CC*01:02,05:01
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 19Y
Category Cancer cell line
STR profile Source(s): CBA=CBA-1383; PubMed=32567790

Markers:
AmelogeninX,Y
CSF1PO11,12
D2S133823,25
D3S135815,16
D5S8189,12
D7S82010,12
D8S117911,14
D13S31710,11
D16S53911,12
D18S5112
D19S43312,13
D21S1128,29
FGA20,23
Penta D9,13
Penta E5,16
TH017
TPOX8
vWA14,17

Run an STR similarity search on this cell line
Publications

PubMed=11216673; DOI=10.3727/096504001108747620
Parmar J., Marshall E.S., Charters G.A., Holdaway K.M., Shelling A.N., Baguley B.C.
Radiation-induced cell cycle delays and p53 status of early passage melanoma cell lines.
Oncol. Res. 12:149-155(2000)

PubMed=20041153; DOI=10.1371/journal.pone.0008461; PMCID=PMC2794539
Jeffs A.R., Glover A.C., Slobbe L.J., Wang L., He S.-J., Hazlett J.A., Awasthi A., Woolley A.G., Marshall E.S., Joseph W.R., Print C.G., Baguley B.C., Eccles M.R.
A gene expression signature of invasive potential in metastatic melanoma cells.
PLoS ONE 4:E8461-E8461(2009)

CLPUB00227
Daukste L.
Mathematical modelling of cancer cell population dynamics.
Thesis PhD (2012); University of Canterbury; Christchurch; New Zealand

PubMed=22475322; DOI=10.1186/1471-2407-12-141; PMCID=PMC3352269
Kim J.E., Stones C.J., Joseph W.R., Leung E.Y., Finlay G.J., Shelling A.N., Phillips W.A., Shepherd P.R., Baguley B.C.
Comparison of growth factor signalling pathway utilisation in cultured normal melanocytes and melanoma cell lines.
BMC Cancer 12:141.1-141.10(2012)

PubMed=23755070; DOI=10.3389/fgene.2013.00097; PMCID=PMC3668138
Kim J.E., Leung E.Y., Baguley B.C., Finlay G.J.
Heterogeneity of expression of epithelial-mesenchymal transition markers in melanocytes and melanoma cell lines.
Front. Genet. 4:97.1-97.8(2013)

PubMed=32567790; DOI=10.1111/pcmr.12908; PMCID=PMC7818249
Tran K.B., Gimenez G., Tsai P., Kolekar S., Rodger E.J., Chatterjee A., Jabed A., Shih J.-H., Joseph W.R., Marshall E.S., Wang Q., Print C.G., Eccles M.R., Baguley B.C., Shepherd P.R.
Genomic and signalling pathway characterization of the NZM panel of melanoma cell lines: a valuable model for studying the impact of genetic diversity in melanoma.
Pigment Cell Melanoma Res. 34:136-143(2021)

Cross-references
Cell line collections (Providers) CBA; CBA-1383
Cell line databases/resources cancercelllines; CVCL_D818
Biological sample resources BioSample; SAMN07624441
BioSample; SAMN14558321
Encyclopedic resources Wikidata; Q54931528
Polymorphism and mutation databases Cosmic; 1660300
Entry history
Entry creation22-Oct-2012
Last entry update19-Dec-2024
Version number21