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Cellosaurus PC9-OR3 (CVCL_D7FI)

[Text version]
Cell line name PC9-OR3
Accession CVCL_D7FI
Resource Identification Initiative To cite this cell line use: PC9-OR3 (RRID:CVCL_D7FI)
Comments Population: Chinese; Han and Japanese.
Selected for resistance to: ChEBI; CHEBI:90943; Osimertinib (AZD9291).
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations
  • Mutation; HGNC; 3236; EGFR; Simple; p.Glu746_Ala750del (c.2235_2249del15); ClinVar=VCV000163343; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_B260 (PC-9)
Sex of cell Male
Age at sampling 45Y
Category Cancer cell line
Publications

PubMed=31555510; DOI=10.21037/tlcr.2019.08.22; PMCID=PMC6749116
Codony-Servat J., Viteri S., Codony-Servat C., Ito M., Bracht J.W.P., Berenguer J., Chaib I., Molina-Vila M.A., Karachaliou N., Rosell R.
Hsp90 inhibitors enhance the antitumoral effect of osimertinib in parental and osimertinib-resistant non-small cell lung cancer cell lines.
Transl. Lung Cancer Res. 8:340-351(2019)

Entry history
Entry creation10-Sep-2024
Last entry update10-Sep-2024
Version number1