ID   M255
AC   CVCL_D756
DR   ArrayExpress; E-MTAB-5493
DR   cancercelllines; CVCL_D756
DR   Cosmic; 1425346
DR   Cosmic; 1665015
DR   Wikidata; Q54903568
RX   PubMed=20406486;
RX   PubMed=22515704;
RX   PubMed=24735930;
RX   PubMed=29229836;
CC   Doubling time: 48.6 hours (PubMed=20406486).
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=20406486).
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=20406486).
CC   Omics: Transcriptome analysis by RNAseq.
DI   NCIt; C3224; Melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Sex unspecified
AG   Age unspecified
CA   Cancer cell line
DT   Created: 22-10-12; Last updated: 19-12-24; Version: 14
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RX   PubMed=20406486; DOI=10.1186/1479-5876-8-39; PMCID=PMC2876068;
RA   Sondergaard J.N., Nazarian R., Wang Q., Guo D.-L., Hsueh T., Mok S.,
RA   Sazegar H., MacConaill L.E., Barretina J.G., Kehoe S.M., Attar N.,
RA   von Euw E.M., Zuckerman J.E., Chmielowski B., Comin-Anduix B.,
RA   Koya R.C., Mischel P.S., Lo R.S., Ribas A.;
RT   "Differential sensitivity of melanoma cell lines with BRAFV600E
RT   mutation to the specific Raf inhibitor PLX4032.";
RL   J. Transl. Med. 8:39.1-39.11(2010).
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RX   PubMed=22515704; DOI=10.1186/1476-4598-11-22; PMCID=PMC3444881;
RA   von Euw E.M., Atefi M., Attar N., Chu C., Zachariah S., Burgess B.L.,
RA   Mok S., Ng C., Wong D.J.L., Chmielowski B., Lichter D.I., Koya R.C.,
RA   McCannel T.A., Izmailova E., Ribas A.;
RT   "Antitumor effects of the investigational selective MEK inhibitor
RT   TAK733 against cutaneous and uveal melanoma cell lines.";
RL   Mol. Cancer 11:22.1-22.9(2012).
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RX   PubMed=24735930; DOI=10.1186/1476-4598-13-83; PMCID=PMC4021505;
RA   Lassen A., Atefi M., Robert L., Wong D.J.L., Cerniglia M.,
RA   Comin-Anduix B., Ribas A.;
RT   "Effects of AKT inhibitor therapy in response and resistance to BRAF
RT   inhibition in melanoma.";
RL   Mol. Cancer 13:83.1-83.14(2014).
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RX   PubMed=29229836; DOI=10.1073/pnas.1712064115; PMCID=PMC5748184;
RA   Su Y.-P., Wei W., Robert L., Xue M., Tsoi J., Garcia-Diaz A.,
RA   Homet Moreno B., Kim J., Ng R.H.-Y., Lee J.W., Koya R.C.,
RA   Comin-Anduix B., Graeber T.G., Ribas A., Heath J.R.;
RT   "Single-cell analysis resolves the cell state transition and signaling
RT   dynamics associated with melanoma drug-induced resistance.";
RL   Proc. Natl. Acad. Sci. U.S.A. 114:13679-13684(2017).
//