ID   hmel1
AC   CVCL_D722
SY   Hmel1; Hmel-1
DR   cancercelllines; CVCL_D722
DR   Cosmic; 1676366
DR   Cosmic; 2051675
DR   Wikidata; Q54889924
RX   DOI=10.1186/1479-5876-12-S1-P7;
RX   PubMed=21880213;
RX   PubMed=23489693;
RX   PubMed=25623468;
RX   PubMed=27540956;
CC   Population: Caucasian; Italian.
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Lys (c.1798_1799delGTinsAA); ClinVar=VCV000375941; Zygosity=Heterozygous (PubMed=21880213; PubMed=23489693).
CC   Sequence variation: Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Trp383Cys (c.1149G>T); Zygosity=Unspecified (PubMed=23489693).
CC   Derived from site: Metastatic; Skin; UBERON=UBERON_0002097.
DI   NCIt; C3224; Melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   70Y
CA   Cancer cell line
DT   Created: 22-10-12; Last updated: 19-12-24; Version: 14
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RX   DOI=10.1186/1479-5876-12-S1-P7;
RA   Azzariti A., Porcelli L., Quatrale A.E., Sidella L., Iacobazzi R.M.,
RA   Guida G., Maida I., Cocco T., Ferretta A., Strippoli S., Guida S.,
RA   Tommasi S., Paradiso A., Guida M.;
RT   "Barasertib: a novel approach for the treatment of metastatic melanoma.";
RL   J. Transl. Med. 12 Suppl. 1:P7-P7(2014).
//
RX   PubMed=21880213;
RA   Zanna P., Maida I., Turpin Sevilla M.C., Susca F.C., Filotico R.,
RA   Arciuli M., Cassano N., Vena G.A., Cicero R., Guida G.;
RT   "Molecular characterization of novel melanoma cell lines.";
RL   J. Biol. Regul. Homeost. Agents 25:239-247(2011).
//
RX   PubMed=23489693;
RA   Zanna P., Maida I., Grieco C., Guida S., Turpin Sevilla M.C.,
RA   De Summa S., Tommasi S., Vena G.A., Filotico R., Guida G.;
RT   "Three novel human sporadic melanoma cell lines: signaling pathways
RT   controlled by MC1R, BRAF and beta-catenins.";
RL   J. Biol. Regul. Homeost. Agents 27:131-141(2013).
//
RX   PubMed=25623468; DOI=10.1186/s12967-015-0385-4; PMCID=PMC4314759;
RA   Porcelli L., Guida G., Quatrale A.E., Cocco T., Sidella L., Maida I.,
RA   Iacobazzi R.M., Ferretta A., Stolfa D.A., Strippoli S., Guida S.,
RA   Tommasi S., Guida M., Azzariti A.;
RT   "Aurora kinase B inhibition reduces the proliferation of metastatic
RT   melanoma cells and enhances the response to chemotherapy.";
RL   J. Transl. Med. 13:26.1-26.13(2015).
//
RX   PubMed=27540956; DOI=10.1111/pcmr.12516;
RA   Guida M., Strippoli S., Ferretta A., Bartolomeo N., Porcelli L.,
RA   Maida I., Azzariti A., Tommasi S., Grieco C., Guida S., Albano A.,
RA   Lorusso V., Guida G.;
RT   "Detrimental effects of melanocortin-1 receptor (MC1R) variants on the
RT   clinical outcomes of BRAF V600 metastatic melanoma patients treated
RT   with BRAF inhibitors.";
RL   Pigment Cell Melanoma Res. 29:679-687(2016).
//