Cellosaurus cell line BT142 (CVCL

Cellosaurus BT142 (CVCL_D718)

[Text version]

Cell line name

BT142

Accession

CVCL_D718

Resource Identification Initiative

To cite this cell line use: BT142 (RRID:CVCL_D718)

Comments

Group: Cancer stem cell line.
Population: Caucasian.
Derived from site: In situ; Brain, left frontal lobe; UBERON=UBERON_0002811.

Sequence variations

Mutation; HGNC; HGNC:5382; IDH1; Simple; p.Arg132His (c.395G>A); ClinVar=VCV000156444; Zygosity=Heterozygous (PubMed=22166263).

Disease

Oligoastrocytoma (NCIt: C4050)
Oligoastrocytoma (ORDO: Orphanet_251656)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Children:

CVCL_X501 (BT142 mut/-)

Sex of cell

Male

Age at sampling

38Y

Category

Cancer cell line

Publications

PubMed=22166263; DOI=10.1093/neuonc/nor207; PMCID=PMC3266388
Luchman H.A., Stechishin O.D.M., Dang N.H., Blough M.D., Chesnelong C., Kelly J.J.P., Nguyen S.A., Chan J.A.W., Weljie A.M., Cairncross J.G., Weiss S.
An in vivo patient-derived model of endogenous IDH1-mutant glioma.
Neuro-oncol. 14:184-191(2012)

PubMed=33504762; DOI=10.1038/s41467-020-20752-6; PMCID=PMC7840755
Lita A., Pliss A., Kuzmin A., Yamasaki T., Zhang L.-M., Dowdy T., Burks C., de Val N., Celiku O., Ruiz-Rodado V., Nicoli E.-R., Kruhlak M.J., Andresson T., Das S., Yang C.-Z., Schmitt R., Herold-Mende C., Gilbert M.R., Prasad P.N., Larion M.
IDH1 mutations induce organelle defects via dysregulated phospholipids.
Nat. Commun. 12:614.1-614.16(2021)

Cross-references

Cell line databases/resources

cancercelllines; CVCL_D718

Encyclopedic resources

Wikidata; Q54798487

Polymorphism and mutation databases

Cosmic; 1629581
Cosmic; 2012330

Entry history

Entry creation

22-Oct-2012

Last entry update

19-Dec-2024

Version number