ID   L2975
AC   CVCL_D706
DR   cancercelllines; CVCL_D706
DR   Cosmic; 1602481
DR   Cosmic; 1755115
DR   Wikidata; Q54901006
RX   PubMed=22057234;
RX   PubMed=22928481;
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=22928481).
CC   Sequence variation: Mutation; HGNC; HGNC:5383; IDH2; Simple; p.Arg172Trp (c.514A>T); ClinVar=VCV000376438; Zygosity=Heterozygous (PubMed=22057234; PubMed=22928481).
CC   Omics: Array-based CGH.
CC   Miscellaneous: STR profile from personal communication of Cleton-Jansen, Anne-Marie.
CC   Derived from site: Metastatic; Bone, spine; UBERON=UBERON_0001130.
ST   Source(s): Direct_author_submission
ST   Amelogenin: X,Y
ST   CSF1PO: 13
ST   D13S317: 12
ST   D16S539: 11
ST   D21S11: 28,29
ST   D5S818: 12
ST   D7S820: 9
ST   TH01: 7
ST   TPOX: 8
ST   vWA: 14
DI   NCIt; C6476; Dedifferentiated chondrosarcoma
DI   ORDO; Orphanet_55880; Chondrosarcoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   57Y
CA   Cancer cell line
DT   Created: 22-10-12; Last updated: 19-12-24; Version: 20
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RX   PubMed=22057234; DOI=10.1038/ng.1004; PMCID=PMC3427908;
RA   Marfatia T., van Eijk R., d'Adamo P., van Ruler M.A.J.H.,
RA   Kuijjer M.L., Oosting J., Cleton-Jansen A.-M., van Oosterwijk J.G.,
RA   Verbeke S.L.J., Meijer D., van Wezel T., Nord K.H., Sangiorgi L.,
RA   Toker B., Liegl-Atzwanger B., San-Julian M., Sciot R., Limaye N.,
RA   Kindblom L.-G., Daugaard S., Godfraind C., Boon L.M., Vikkula M.,
RA   Kurek K.C., Szuhai K., French P.J., Bovee J.V.M.G.;
RT   "Somatic mosaic IDH1 and IDH2 mutations are associated with
RT   enchondroma and spindle cell hemangioma in Ollier disease and Maffucci
RT   syndrome.";
RL   Nat. Genet. 43:1256-1261(2011).
//
RX   PubMed=22928481; DOI=10.1186/1471-2407-12-375; PMCID=PMC3484068;
RA   van Oosterwijk J.G., de Jong D., van Ruler M.A.J.H., Hogendoorn P.C.W.,
RA   Dijkstra P.D.S., van Rijswijk C.S.P., Machado I., Llombart-Bosch A.,
RA   Szuhai K., Bovee J.V.M.G.;
RT   "Three new chondrosarcoma cell lines: one grade III conventional
RT   central chondrosarcoma and two dedifferentiated chondrosarcomas of
RT   bone.";
RL   BMC Cancer 12:375.1-375.10(2012).
//