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Cellosaurus A-673 EHD1 KO (CVCL_D6TY)

[Text version]
Cell line name A-673 EHD1 KO
Synonyms EHD1-KO A673
Accession CVCL_D6TY
Resource Identification Initiative To cite this cell line use: A-673 EHD1 KO (RRID:CVCL_D6TY)
Comments Problematic cell line: Misclassified. Parent cell line (A-673) was originally thought to be a rhabdomyosarcoma cell line but is an Ewing sarcoma cell line.
Population: Caucasian.
Knockout cell: Method=CRISPR/Cas9; HGNC; 3242; EHD1.
Derived from site: In situ; Muscle; UBERON=UBERON_0001630.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene fusion; HGNC; 3508; EWSR1 + HGNC; 3749; FLI1; Name(s)=EWSR1-FLI1, EWS-FLI1; Note=Type 1 fusion (Ex7/Ex6) (from parent cell line).
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Ala119Glnfs*5 (c.353_354dupCA) (c.354_355insCA); Zygosity=Homozygous (from parent cell line).
Disease Ewing sarcoma (NCIt: C4817)
Ewing sarcoma (ORDO: Orphanet_319)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0080 (A-673)
Sex of cell Female
Age at sampling 15Y
Category Cancer cell line
Publications

PubMed=37474760; DOI=10.1038/s42003-023-05125-1; PMCID=PMC10359273
Chakraborty S., Bhat A.M., Mushtaq I., Luan H.-T., Kalluchi A., Mirza S., Storck M.D., Chaturvedi N., Lopez-Guerrero J.A., Llombart-Bosch A., Machado I., Scotlandi K., Meza J.L., Ghosal G., Coulter D.W., Rowley M.J., Band V., Mohapatra B.C., Band H.
EHD1-dependent traffic of IGF-1 receptor to the cell surface is essential for Ewing sarcoma tumorigenesis and metastasis.
Commun. Biol. 6:758.1-758.21(2023)

Entry history
Entry creation10-Sep-2024
Last entry update10-Sep-2024
Version number1