| Cell line name |
TC-71 EHD1 KO |
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| Synonyms |
EHD1-KO TC71 |
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| Accession |
CVCL_D6TX |
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| Resource Identification Initiative |
To cite this cell line use: TC-71 EHD1 KO (RRID:CVCL_D6TX) |
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| Comments |
Population: Caucasian.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:3242; EHD1.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Bone, humerus; UBERON=UBERON_0000976. |
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| Sequence variations |
- Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
- Gene fusion; HGNC; HGNC:3508; EWSR1 + HGNC; HGNC:3749; FLI1; Name(s)=EWSR1-FLI1, EWS-FLI1 (from parent cell line).
- Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Arg233Ter (c.697C>T); ClinVar=VCV000007813; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg213Ter (c.637C>T); ClinVar=VCV000043590; Zygosity=Unspecified (from parent cell line).
|
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| Disease |
Ewing sarcoma (NCIt: C4817)
Ewing sarcoma (ORDO: Orphanet_319) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_2213 (TC-71) |
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| Sex of cell |
Male |
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| Age at sampling |
22Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=37474760; DOI=10.1038/s42003-023-05125-1; PMCID=PMC10359273
Chakraborty S., Bhat A.M., Mushtaq I., Luan H.-T., Kalluchi A., Mirza S., Storck M.D., Chaturvedi N., Lopez-Guerrero J.A., Llombart-Bosch A., Machado I., Scotlandi K., Meza J.L., Ghosal G., Coulter D.W., Rowley M.J., Band V., Mohapatra B.C., Band H.
EHD1-dependent traffic of IGF-1 receptor to the cell surface is essential for Ewing sarcoma tumorigenesis and metastasis.
Commun. Biol. 6:758.1-758.21(2023) |
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| Entry history |
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| Entry creation | 10-Sep-2024 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 2 |
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