| Cell line name |
TC-71 EHD1 KO |
|---|
| Synonyms |
EHD1-KO TC71 |
|---|
| Accession |
CVCL_D6TX |
|---|
| Resource Identification Initiative |
To cite this cell line use: TC-71 EHD1 KO (RRID:CVCL_D6TX) |
|---|
| Comments |
Population: Caucasian.
Knockout cell: Method=CRISPR/Cas9; HGNC; 3242; EHD1.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Bone, humerus; UBERON=UBERON_0000976. |
|---|
| Sequence variations |
- Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
- Gene fusion; HGNC; 3508; EWSR1 + HGNC; 3749; FLI1; Name(s)=EWSR1-FLI1, EWS-FLI1 (from parent cell line).
- Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 9588; PTEN; Simple; p.Arg233Ter (c.697C>T); ClinVar=VCV000007813; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Arg213Ter (c.637C>T); ClinVar=VCV000043590; Zygosity=Unspecified (from parent cell line).
|
|---|
| Disease |
Ewing sarcoma (NCIt: C4817)
Ewing sarcoma (ORDO: Orphanet_319) |
|---|
| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
|---|
| Hierarchy |
Parent: CVCL_2213 (TC-71) |
|---|
| Sex of cell |
Male |
|---|
| Age at sampling |
22Y |
|---|
| Category |
Cancer cell line |
|---|
| Publications | PubMed=37474760; DOI=10.1038/s42003-023-05125-1; PMCID=PMC10359273
Chakraborty S., Bhat A.M., Mushtaq I., Luan H.-T., Kalluchi A., Mirza S., Storck M.D., Chaturvedi N., Lopez-Guerrero J.A., Llombart-Bosch A., Machado I., Scotlandi K., Meza J.L., Ghosal G., Coulter D.W., Rowley M.J., Band V., Mohapatra B.C., Band H.
EHD1-dependent traffic of IGF-1 receptor to the cell surface is essential for Ewing sarcoma tumorigenesis and metastasis.
Commun. Biol. 6:758.1-758.21(2023) |
|---|
| Entry history |
|---|
| Entry creation | 10-Sep-2024 |
|---|
| Last entry update | 10-Sep-2024 |
|---|
| Version number | 1 |
|---|
